Summary
The release of insulinin vitro from isolated mouse islets was significantly inhibited in the presence of an islet protein extract equivalent to more than 100 times the normal serum level of insulin. The nature of the inhibitory islet substance remains unclear. The possibility that the blood circulation through the islets may be important for the local regulation of insulin release by reducing high levels of this hormone in the immediate surroundings of theβ cells should be considered.
Résumé
La libérationin vitro d'insuline par les îlots isolés de souris fut significativement réduite en présence d'un extrait de protéine îlotique contenant plus de 100 fois le taux normal d'insuline dans le sérum. La nature de la substance répressive d'origine insulaire reste obscure. La possibilité que la circulation de sang à travers les îlots puisse avoir de l'importance pour la régulation locale de la libération d'insuline en réduisant les taux élevés de cette hormone à proximité immédiate des cellules bêta doit être considérée.
Zusammenfassung
Die Freisetzung von Insulin aus isolierten Mäuseinselnin vitro wurde in Gegenwart eines Proteinextraktes aus Langerhans'schen Inseln, das mehr als das Hundertfache der normalen Insulinmenge im Serum enthielt, merklich gehemmt. Die Natur dieses Hemmfaktors bleibt unklar. Man sollte die Möglichkeit besonders berücksichtigen, daß die Durchblutung der Inseln für die lokale Regelung der Insulinfreisetzung über eine Reduktion der hohen Konzentration dieses Hormons in der unmittelbaren Umgebung derβ-Zellen von Bedeutung sein kann.
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Part of a project supported by the United States Public Health Service (AM-12535), Swedish Medical Research Council (12×-562) and the Medical Faculty of Umeå.
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Hellman, B., Lernmark, Å. Evidence for an inhibitor of insulin release in the pancreatic islets. Diabetologia 5, 22–24 (1969). https://doi.org/10.1007/BF01212214
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DOI: https://doi.org/10.1007/BF01212214