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Immunotoxins up to the present day

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Bioscience Reports

Abstract

Immunotoxins consist of monoclonal or polyclonal antibodies conjugated to bacterial or plant toxins. The toxins used are typically of the A-B type in which a toxic A chain is coupled to a B chain responsible for cell binding and facilitation of A chain entry into the cytosol. Two broad strategies have been followed: coupling intact toxins, or A chains alone, to antibodies. This review examines current progress inin vitro andin vivo research, including recent clinical studies, concentrating principally on ricin or ricin A chain conjugates. The future role of conjugates using membrane-acting toxins, immunolysins, is also discussed.

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  1. St Bartholomew's Hospital Medical College, College Hall, Charterhouse Square, EC1, London

    Francis A. Drobniewski

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  1. Francis A. Drobniewski
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Drobniewski, F.A. Immunotoxins up to the present day. Biosci Rep 9, 139–156 (1989). https://doi.org/10.1007/BF01115993

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