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Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtainedin vitro as well as on physiological data

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Abstract

Ethoxybenzamide (EB) concentrations in plasma and various tissues were simulated using a physiological pharmacokinetic model. The biochemical parameters, such as plasma and tissue binding constants and Michaelis-Menten constants for EB deethylation, which were needed for these simulations, were, however, obtained from in vitro data. The simulations predicted well the observed data in plasma and various tissues of the rat. Furthermore, animal scale-up predicted reasonably well the concentrations of EB in plasma and various tissues of the rabbit from data gathered in rats.

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Author notes

  1. Jiunn Huei Lin

    Present address: Drug Metabolism Section, Merck Sharp Dohme Research Laboratory, 19486, West Point, Pennsylvania

Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Jiunn Huei Lin, Yuichi Sugiyama & Manabu Hanano

  2. Department of Biopharmaceutics, Tokyo College of Pharmacy, Horinouchi, Hachioji, 192-03, Tokyo, Japan

    Shoji Awazu

Authors
  1. Jiunn Huei Lin
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  2. Yuichi Sugiyama
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  3. Shoji Awazu
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  4. Manabu Hanano
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Additional information

This work was supported by a grant-in-aid for scientific research provided by the Ministry of Education, Japan.

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Lin, J.H., Sugiyama, Y., Awazu, S. et al. Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtainedin vitro as well as on physiological data. Journal of Pharmacokinetics and Biopharmaceutics 10, 649–661 (1982). https://doi.org/10.1007/BF01062546

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  • DOI: https://doi.org/10.1007/BF01062546

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