Abstract
In vitroand in vivocorrelations of the microsomal oxidation of drugs were examined, using ethoxybenzamide as a model drug. Ethoxybenzamide disappearance time course from rat plasma in vivowas analyzed by a two-compartment model assuming a Michaelis-Menten type elimination process. Ethoxybenazmide oxidation in vitrowas measured by the appearance rate of salicylamide in rat liver microsomal suspension. Parameters obtained were Vmax=3.46 and 3.77 μmoles/min/kg body weight and Km=0.378 and 0.192mM, in vitroand in vivo,respectively.
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Lin, J.H., Hayashi, M., Awazu, S. et al. Correlation betweenin vitro andin vivo drug metabolism rate: Oxidation of ethoxybenzamide in rat. Journal of Pharmacokinetics and Biopharmaceutics 6, 327–337 (1978). https://doi.org/10.1007/BF01060096
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DOI: https://doi.org/10.1007/BF01060096