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Action of caerulein and related substances on the sphincter of Oddi

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Summary

The effects of caerulein and some related substances were investigated on the sphincter of Oddi which had been contracted by morphine in the guinea-pig, and on the isolated terminal bile duct in the calf. In the first test caerulein (50–100 ng/kg i.v.) was the most potent spasmolytic drug whereas in the second test the peptide (0.75-1 Μg/ml) produced actually a spasmogenic effect. The peptide resembled epinephrine in both preparations.

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Authors and Affiliations

  1. Institute of Pharmacology, University of Parma, Parma, Italy

    A. Agosti, P. Mantovani & L. Mori

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  1. A. Agosti
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  2. P. Mantovani
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  3. L. Mori
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Agosti, A., Mantovani, P. & Mori, L. Action of caerulein and related substances on the sphincter of Oddi. Naunyn-Schmiedebergs Arch. Pharmak. 268, 114–118 (1971). https://doi.org/10.1007/BF00997178

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  • DOI: https://doi.org/10.1007/BF00997178

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