Abstract
Gastrointestinal (GI) motility is an essential function of the gastrointestinal tract, which is regulated by various neurohumoural factors and drugs. The neurohumoural control is mediated by the enteric nervous system (ENS), the autonomic nervous system (ANS), and local and circulating hormones. The principal local hormones that modulate gut motility are ghrelin, cholecystokinin (CCK), motilin, glucagon like peptide-1 (GLP-1), serotonin and dopamine. Also, various drugs can modulate the gastrointestinal motility. Prokinetic drugs stimulate GI motility and smooth muscle relaxants suppress the motility. Dopamine receptor antagonists (like metoclopramide, domperidone), serotonin receptor agonists (like cisapride, mosapride, itopride and prucalopride), macrolide antibiotics (like erythromycin) and sincalide are classified as prokinetic agents. Organic nitrates, phosphodiesterase type 5 inhibitors, calcium channel blockers and botulinum toxin are smooth muscle relaxants that suppress the GI motility.
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Bibliography
Acosta A, Camilleri M (2015) Prokinetics in gastroparesis. Gastroenterol Clin N Am 44:97–111. https://doi.org/10.1016/j.gtc.2014.11.008
Georgiadis T, Markantonis-Kyroudis S, Triantafillidis J (2000) Prokinetic agents: current aspects with focus on cisapride. Ann Gastroenterol 13(4):269–289
Isola S, Adams N (2019) Metoclopramide. StatPearls Publishing, Treasure Island. https://www.ncbi.nlm.nih.gov/books/NBK519517/
McQuaid KR (2018) Drugs used in the treatment of gastrointestinal diseases. In: Katzung BG (ed) Basic and clinical pharmacology, 14th edn. McGraw-Hill, New York, pp 1096–1098
Quigley EM (2015) Prokinetics in the management of functional gastrointestinal disorders. J Neurogastroenterol Motil 21(3):330–336. https://doi.org/10.5056/jnm15094
Sharkey KA, MacNaughton WK (2018) Gastrointestinal motility and water flux, emesis, and biliary and pancreatic disease. In: Brunton LL, Dandan RH, Knollmann BC (eds) Goodman &Gilman’s the pharmacological basis of therapeutics, 13th edn. McGraw-Hill, New York, pp 921–925
Wu GY (2003) The pharmacology of prokinetic agents and their role in the treatment of gastro intestinal disorders. Int J Gastroenterol 1(4):6–13
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Anandabaskar, N. (2021). Drugs Affecting Gastrointestinal Motility. In: Paul, A., Anandabaskar, N., Mathaiyan, J., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-33-6009-9_35
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DOI: https://doi.org/10.1007/978-981-33-6009-9_35
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