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Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin

  • Special Issue: Molecular Pathology
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Conclusion

Metastasis determines cancer malignancy. Neoplastic cells metastasize through a multistep process of invasion. At each step, these cells create a dynamic micro-ecosystem in which the elements of the host are considered to paricipate actively invasion. Within such micro-ecosystems, invasion is believed to be governed by a balance between the activation of promoter (i-minus) and suppressor (i-plus) genes. Products of such genes regulate the expression of the invasive (I-plus) and the nonivasive (I-minus) phenotypes. Experimentsin vitro andin vivo, as well as observations on human cancers have put forward the cell-cell adhesion molecule E-cadherin (L-CAM; uvomorulin) as a regulator of epithelial organization and an invasion suppressor.

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  1. Department of Radiotherapy, Nuclear Medicine and Experimental Cancerology, University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium

    Marc Mareel & Marc Bracke

  2. Laboratory of Molecular Cell Biology, Department of Molecular Genetics, University of Ghent, K.L., Ledeganckstraat 35, B-9000, Ghent, Belgium

    Frans Van Roy

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Mareel, M., Bracke, M. & Van Roy, F. Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin. Mol Biol Rep 19, 45–67 (1994). https://doi.org/10.1007/BF00987321

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