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Role of Magnetic Resonance Spectroscopy in Clinical Management of Brain Tumors

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Atlas of Clinical Cases on Brain Tumor Imaging

Abstract

Following the basic principles and basic and advanced protocols, we will provide an overview, with tables, of the role of magnetic resonance spectroscopy (MRS) and the clinical features in which MRS will be used in the clinical management of brain tumors.

For example, MRS could be used before brainstem biopsies for brainstem lesions with mass effect or to differentiate necrotic masses. MRS is also used to predict survival, tumor activity, and early progression. It is used to monitor treatments: chemotherapy (e.g., Temozolomide), new sources of radiation (stereotactic, proton, and Hadron therapy), antiangiogenic and immune therapies, tumoral interventional therapies, and symptomatic treatments.

Important metabolites and ratios that affect clinical management will be explained or presented, such as Choline/Creatine (Cho/Cr) and Choline/N-acetyl aspartate (Cho/NAA), Lactate (Lac), and Lac/Cr, Glucose (Glc), Glutamine (Gln), CH2 Lipids (CH2-Lip), Taurine (Tau), Citrate (Cit), and Alanine (Ala). The importance of analysis of the whole spectral profile is emphasized with the help of multidimensional analysis and artificial intelligence.

Finally, a brief overview and table of practical clinical cases of brain tumor MRS, such as in glioblastomas (GBM), gliomas, metastases, lymphomas, meningiomas, and necrotic tumors, will be presented.

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Authors and Affiliations

  1. Neuroradiology Department, Amiens Picardie University Hospital and EA7516 CHIMERE of University Picardie Jules Verne, Amiens, France

    Adrien Heintz & Jean-Marc Constans

Authors
  1. Adrien Heintz
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  2. Jean-Marc Constans
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Correspondence to Jean-Marc Constans .

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Editors and Affiliations

  1. Radiology Department, Adnan Menderes University, Aydın, Turkey

    Yelda Özsunar

  2. School of Medicine, Akdeniz University, Antalya, Turkey

    Utku Åženol

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Heintz, A., Constans, JM. (2020). Role of Magnetic Resonance Spectroscopy in Clinical Management of Brain Tumors. In: Özsunar, Y., Şenol, U. (eds) Atlas of Clinical Cases on Brain Tumor Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-23273-3_5

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  • DOI: https://doi.org/10.1007/978-3-030-23273-3_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23272-6

  • Online ISBN: 978-3-030-23273-3

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