Summary
80% of cultures of foetal human and rat muscle underwent destruction when incubated with lymphocytes from patients with polymyositis compared with 30% of those incubated with serum from patients with polymyositis and 25% of those incubated with lymphocytes from patients with other neurological disorders. Cultures of dural fibroblasts were also destroyed in the presence of lymphocytes from patients suffering from polymyositis associated with collagen disorders. These effects may be the sequel to a specific sensitization of lymphocytesin vivo and the findings are therefore consistent with a mechanism of cellmediated hypersensitivity underlying polymyositis.
Zusammenfassung
80% der Kulturen von fetalem menschlichen und Rattenmuskel wurden zerstört, wenn sie mit Lymphocyten von Patienten mit Polymyositis inkubiert wurden, im Gegensatz zu 30% zerstörter Kulturen von jenen, die mit Serum von Polymyositispatienten und 25% von jenen, die mit Lymphocyten von Patienten mit anderen neurologischen Krankheiten inkubiert wurden. Kulturen von Durafibroblasten wurden in Gegenwart von Lymphocyten von Patienten, die an Polymyositis in Verbindung mit Kollagenkrankheiten litten, ebenfalls zerstört. Diese Wirkungen könnten die Folge einer spezifischen Sensibilisierung von Lymphocyten in vivo sein; diese Befunde stehen daher in Einklang mit der Annahme eines Mechanismus von cellulär übertragener Hypersensibilität als Grundlage der Polymyositis.
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The work was aided by grants from the Medical Research Council, the Muscular Dystrophy Association of America, Inc., and the Muscular Dystrophy Group of Great Britain. The author would like to thank Miss Aileen Brown for her advice and technical assistance, his co-workers. Dr. Michael Saunders and Mr. Malcolm Knowles of the M.R.C. Demyelinating Diseases Research Unit, the physicians of the region for allowing him to study their patients and Prof. John N. Walton for his advice and encouragement.
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Currie, S. Destruction of muscle cultures by lymphocytes from cases of polymyositis. Acta Neuropathol 15, 11–19 (1970). https://doi.org/10.1007/BF00690685
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DOI: https://doi.org/10.1007/BF00690685