Skip to main content
SpringerLink
Log in

Structural changes of the central nervous system in swayback (Enzootic Ataxia) of lambs

II. Electron microscopy of the lower motor neuron

  • Original Investigation
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

The ultrastructure of the nerve cell change in swayback is presented. Notable features are an increase in cell size, progressive loss of Nissl substance, alteration in form and distribution of the Golgi apparatus and a striking increase in neurofibrils within the perikaryon. Similarities and differences in the fine structural changes of other pathological states are discussed.

Zusammenfassung

Die Ultrastruktur der Veränderungen in der Nervenzelle beim “Swayback” (enzootische Ataxia) wird dargestellt. Erwähnenswert sind Zunahme des Zellumfangs, fortschreitender Schwund von Nissl-Substanz, Veränderungen der Form und der Verteilung des Golgiapparats sowie eine auffallende Vermehrung von Neurofibrillen innerhalb des Perikaryons. Ähnliche und abweichende Veränderungen der Feinstruktur verschiedener pathologischer Zustände werden besprochen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Barlow, R. M., andP. A. Cancilla: Structural changes of the central nervous system in Swayback disease of lambs. I. Light microscopy using phosphatases as organelle markers. Acta neuropath. (Berl.)6, 175–180 (1966).

    Article  Google Scholar 

  • —,D. Purves, E. J. Butler, andI. Jean Macintyre: Swayback in south-east Scotland. II. Clinical, Pathological and biochemical aspects. J. comp. Path.70, 411–428 (1960).

    Article  CAS  PubMed  Google Scholar 

  • Bodian, D.: An electron microscopic study of the monkey spinal cord. I. Fine structure of normal motor column. II. Effects of retrograde chromatolysis. III. Cytological effects of mild and virulent polio-virus infection. Bull. Johns Hopk. Hosp.114, 13–119 (1964).

    CAS  Google Scholar 

  • Chou, S. M., andH. A. Hartmann: Axonal lesions and waltzing syndrome after I. D. P. N. Administration in rats. With a concept-axostasis. Acta neuropath. (Berl.)3, 428–450 (1963/64).

    Article  Google Scholar 

  • Evans, D. H., andE. G. Gray: Changes in the fine structure of ganglion cells during chromatolysis. In: Cytology of nervous tissue, p. 71. Proc. Anat. Soc. Gr. Brit. and Ireland. London: Taylor and Francis 1961.

    Google Scholar 

  • Holt, S. J., andR. M. Hicks: The localization of acid phosphatase in rat liver cells as revealed by combined cytochemical staining and electron microscopy. J. biophys. biochem. Cytol.11, 47–66 (1961).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hudson, G., A. Lazarow, andJ. F. Hartmann: A quantitative electron microscopic study of mitochondria in motor neurons following axonal section. Exp. Cell Res.24, 440–456 (1961).

    Article  CAS  PubMed  Google Scholar 

  • Kidd, M.: Alzheimer's disease. An electron microscopical study. Brain87, 307–320 (1964).

    Article  CAS  PubMed  Google Scholar 

  • Luft, J. H.: Improvements in epoxy resin embedding methods. J. biophys. biochem. Cytol.9, 409–414 (1961).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Millonig, G.: Advantages of a phosphate buffer for OsO4 solutions in fixation. J. appl. Physiol.32, 1637 (1961).

    Google Scholar 

  • Novikoff, A. B., andE. Essner: Pathological changes in cytoplasmic organelles. Fed. Proc.21, 1130–1142 (1962).

    CAS  PubMed  Google Scholar 

  • Sabatini, D. D., K. Bensch, andR. R. Barnett: Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J. Cell Biol.17, 19–58 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Terry, R. D.: The fine structure of neurofibrillary tangles in Alzheimer's disease. J. Neuropath. exp. Neurol.22, 629–642 (1963).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Pathology, University of Utah, College of Medicine, Salt Lake City, Utah, USA

    P. A. Cancilla & R. M. Barlow

  2. Division of Neurology, University of Utah, College of Medicine, Salt Lake City, Utah, USA

    P. A. Cancilla & R. M. Barlow

  3. The Animal Diseases Research Association, Moredun Institute, Edinburgh, Scotland

    P. A. Cancilla & R. M. Barlow

  4. Henry and Lucy Moses Research Laboratories of the Laboratory Division, Montefiore Hospital, The Bronx, New York

    P. A. Cancilla & R. M. Barlow

Authors
  1. P. A. Cancilla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Barlow
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This investigation was supported by United States Public Health Service Research Grants No. HE-05609-04 and -05 from the National Heart Institute, CA-05321-05 from the National Cancer Institute, National Institutes of Health, and grants from theSandy Schneider Memorial Fund and the Wellcome Trust. A portion of this work was done while Dr.Cancilla was a Special Research Fellow of the National Institute of Neurological Diseases and Blindness (Grant # 2F11-NB1119-02NSRB) and Dr.Barlow was a Fulbright Scholar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cancilla, P.A., Barlow, R.M. Structural changes of the central nervous system in swayback (Enzootic Ataxia) of lambs. Acta Neuropathol 6, 251–259 (1966). https://doi.org/10.1007/BF00687855

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00687855

Keywords

Search

Navigation