Summary
The Golgi apparatus and lysosomes of nerve cells in swayback have been studied. In the nerve cells of the brain stem and spinal cord, changes have been found which accompany the late stages of chromatolysis. In part, these alterations resemble those which occur after section of a nerve, but more striking are the gradual loss of lysosomes and the formation of Golgi agglomerates, features which differ from those described in axonal reaction.
Zusammenfassung
Golgi-Apparat und Lysosomen von Nervenzellen im ZNS an „Swayback” (enzootischer Ataxie) erkrankter Lämmer wurden untersucht. An den Nervenzellen in Hirnstamm und Rückenmark wurden Veränderungen im Zusammenhang mit späten Stadien der Chromatolyse angetroffen. Diese Veränderungen erinnern teilweise an solche nach Nervendurchtrennung, doch treten der allmähliche Verlust der Lysosomen sowie die Bildung von Golgi-Anhäufungen stärker hervor, wodurch sich Abweichungen gegenüber den Veränderungen bei Axon-Reaktionen ergeben.
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This investigation was supported by United States Public Health Service Research Grant No. HE-05609-04 and -05 from the National Heart Institute, National Institutes of Health and grants from the Sandy Schneider Memorial Fund and the Wellcome Trust. A portion of this work was done while Dr.Barlow was a Fulbright Scholar and Dr.Cancilla was a Special Research Fellow of the National Institute of Neurological Diseases and Blindness (Grant No. 2F11-NB1119-02NSRB).
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Barlow, R.M., Cancilla, P.A. Structural changes of the central nervous system in swayback (enzootic ataxia) of lambs. Acta Neuropathol 6, 175–180 (1966). https://doi.org/10.1007/BF00686762
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DOI: https://doi.org/10.1007/BF00686762