Skip to main content
Log in

A comparison of the fine structure of small blood vessels in intracranial and retroperitoneal malignant lymphomas

  • Original Investigations
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

The fine structure of the blood vessels of an apparently primary intracerebral malignant lymphoma was compared with those in another malignant lymphoma in a retroperitoneal lymph node. The essential features of the blood vessels in both cases were the same. They resembled the blood vessels found in normal lymph nodes and were both distinctly different from those seen in normal brain. It was concluded that the direction of differentiation of the blood vessels which arise to nourish the neoplastic tissue is determined by the nature of the tumor rather than the vessels from which they originate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bennet, H. S., Luft, J. H., Hampton, J. C.: Morphological classifications of vertebrate blood capillaries. Amer. J. Physiol.196, 381–390 (1959)

    Google Scholar 

  • Bernhard, W., Leplus, R.: Fine structure of the normal and malignant human lymph node. New York: MacMillan 1964

    Google Scholar 

  • Blackbourne, B. D., Waggener, J. D.: Ultrastructure of a primary cerebral reticuloendothelial sarcoma (microgliomatosis). J. Neuropath. exp. Neurol.26, 141 abst. (1967)

  • Brightman, M. W., Reese, T. S.: Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol.40, 648–677 (1969)

    Google Scholar 

  • Dmochowski, L., Yumoto, T., Grey, C. E., Designer, E., Hales, R. L., Langford, P. L., Taylor, H. G., Freireich, E. J., Schullenberger, C. C., Shively, J. A., Howe, C. D.: Electron microscopic studies of human leukemia and lymphoma. Cancer20, 760–777 (1967)

    Google Scholar 

  • Dorfman, R. F.: The fine structure of a malignant lymphoma in a child from St. Louis, Missouri. J. nat. Cancer Inst.38, 491–504 (1967)

    Google Scholar 

  • Fisher, E. R., Horvat, B. L., Wechsler, H. L.: Ultrastructural features of mycosis fungoides. Amer. J. clin. Path.58, 99–110 (1972)

    Google Scholar 

  • Friedman, B., Hanaoka, H.: Round-cell sarcomas of bone. J. Bone Jt Surg.53, 1118–1136 (1971)

    Google Scholar 

  • Hirano, A., Zimmerman, H. M.: Fenestrated blood vessels in a metastatic renal carcinoma in the brain. Lab. Invest.26, 465–468 (1972)

    Google Scholar 

  • Hirano, A., Hasson, J., Zimmerman, H. M.: Some new fine structural observations of ethylnitrosourea-induced nerve tumors in rats. Lab. Invest.27, 555–560 (1972)

    Google Scholar 

  • Hirano, A., Dembitzer, H. M., Zimmerman, H. M.: Fenestrated blood vessels in neurilemoma. Lab. Invest.27, 305–309 (1972)

    Google Scholar 

  • Hirano, A., Tomiyasu, U., Zimmerman, H. M.: The fine structure of blood vessels in chromophobe adenoma. Acta neuropath. (Berl.)22, 200–207 (1972)

    Google Scholar 

  • Horvat, B., Pena, C., Fisher, E. R.: Primary reticulum cell sarcoma (microglioma) of brain. Arch. Path.87, 609–616 (1969)

    Google Scholar 

  • Iizuka, R., Spalke, G.: Virusähnliche Filament- und Kristalloid-Einschlüsse bei einem Fall von “primärer” Reticuloendotheliose des Gehirns. Acta neuropath. (Berl.)21, 39–49 (1972)

    Google Scholar 

  • Kadin, M., Bensch, K. G.: On the origin of Ewing's tumor. Cancer27, 257–273 (1971)

    Google Scholar 

  • Lennert, K., Niedorf, H. R.: Nachweis von desmosomal verknüpften Reticulumzellen im follikulären Lymphom (Brill-Symmers). Virchows Arch. Ab. B Zellpath.4, 148–150 (1969)

    Google Scholar 

  • Luse, S. A.: Electron-microscopic studies of brain tumors. Neurology (Minneap.)10, 881–905 (1960)

    Google Scholar 

  • Moe, R. E.: Fine structure of the reticulum and sinuses of lymph nodes. Amer. J. Anat.112, 311–335 (1963)

    Google Scholar 

  • Matsuda, H., Sugiura, S.: Ultrastructure of “tubular body” in the endothelial cells of the ocular blood vessels. Invest. Ophthal.9, 919–925 (1970)

    Google Scholar 

  • Okano, H., Azar, H. A., Osserman, E. F.: Plasmacytic reticulum cell sarcoma. A case report with electron microscopic studies. Amer. J. clin. Path.46, 546–555 (1966)

    Google Scholar 

  • Petrozzi, J. W., Raque, C. J., Goldschmidt, H.: Malignant lymphoma, reticulum cell type. Ultrastructural and cytological demonstration of Lutzner cells. Arch. Derm.104, 38–44 (1971)

    Google Scholar 

  • Popoff, N., Stewart, S.: The fine structure of nuclear inclusions in the brain of experimental golden hamsters. J. Ultrastruct. Res.23, 347–361 (1968)

    Google Scholar 

  • Raimondi, A. J., Beckman, F.: Perineurial fibroblastomas: Their fine structure and biology. Acta neuropath. (Berl.)8, 1–23 (1967)

    Google Scholar 

  • Rangan, S. R., Calvert, R. C., Vitols, K.: Fibrillar bundles in canine lymphomas: An ultrastructural study. J. Ultrastruct. Res.36, 425–436 (1971)

    Google Scholar 

  • Reese, T. S., Karnovsky, M. J.: The structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol.34, 207–217 (1967)

    Google Scholar 

  • Rubinstein, L. J.: Tumors of the central nervous system. Washington, D. C.: Armed Forces Institute of Pathology 1972

    Google Scholar 

  • Stehbens, W. E.: Ultrastructure of vascular endothelium in the frog. Quart. J. exp. Physiol.50, 375–384 (1965)

    Google Scholar 

  • Stehbens, W. E.: Pathology of cerebral blood vessels. St. Louis: C. V. Mosby 1972

    Google Scholar 

  • Weibel, E. R., Palade, G. E.: New cytoplasmic components in arterial endothelia. J. Cell Biol.23, 101–112 (1964)

    Google Scholar 

  • Weinberger, M. A., Banfield, W. F.: Fine structure of a transplacentable reticulum cell sarcoma. 1. Light and electron microscopy of viable and necrotic tumor cells. J. nat. Cancer Inst.34, 459–479 (1965)

    Google Scholar 

  • Yoffey, J. M., Courtise, F. C.: Lymphatics, lymph and the lymphomyeloid complex. New York: Academic Press 1970

    Google Scholar 

  • Zimmerman, H. M.: Malignant lymphomas. In: Pathology of the nervous system, J. Minckler, ed., pp. 2165–2178. New York-Toronto-Sydney-London: McGraw Hill 1971

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hirano, A., Ghatak, N.R., Becker, N.H. et al. A comparison of the fine structure of small blood vessels in intracranial and retroperitoneal malignant lymphomas. Acta Neuropathol 27, 93–104 (1974). https://doi.org/10.1007/BF00687160

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00687160

Key words

Navigation