Summary
A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggests that granulovacuolar degeneration may contain phosphorylated proteins, possibly due to autophagy of phosphorylated perikaryal proteins that appear to be increased in Alzheimer's disease.
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Supported in part by NIH grants AG 1136, AG 4145 and NS 7098
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Dickson, D.W., Ksiezak-Reding, H., Davies, P. et al. A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration. Acta Neuropathol 73, 254–258 (1987). https://doi.org/10.1007/BF00686619
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DOI: https://doi.org/10.1007/BF00686619