Summary
One of the major morphological disparities of brain capillaries between newborn or young and adult rats might be reflected in the aspect of development of the basement membrane. The basement membrane in young animals is clearly evident to be poorly developed up to 15 days of age, and then better developed to possess some similarity to that in adult animals. In addition, it also should be emphasized that slightly distended extracellular space is evident in the nervous tissue of newborn animals.
Although in malignant astrocytoma some small blood vessels do not possess any perivascular space around them, others evidently have narrow or relatively wide perivascular spaces where some fibrils of mesodermal origin and fibrocytes can be clearly seen. Also, in some astrocytomas, wide extracellular space is distributed extensively all over the tumor tissue.
However, in this context the immaturity of endothelial and glial cells in both young animals and brain tumors should be duly considered.
The permeability of the brain capillaries in both young animals and brain tumors has been very well known to be higher than that of the adult brain tissue. However, the higher permeability has another significance, from the morphological point of view, in young animals than it has in brain tumors.
Zusammenfassung
Einer der hervorstechendsten morphologischen Unterschiede zwischen den Hirncapillaren neugeborener und junger oder erwachsener Ratten kommt in der Entwicklung der Basalmembran zum Ausdruck. Bei jungen Tieren bis zu einem Alter von 15 Tagen ist die Basalmembran wenig ausgebildet, mit fortschreitendem Alter der Tiere tritt die Ähnlichkeit mit der Basalmembran von erwachsenen Tieren ausgeprägter in Erscheinung. Außerdem ist zu betonen, daß im Nervengewebe neugeborener Tiere etwas erweiterte extracelluläre Räume zu beobachten sind.
Im maligen Astrocytom gibt es kleine Blutgefäße, die keine perivasculären Räume besitzen, andere dagegen haben deutliche engere oder verhältnismäßig weite perivasculäre Räume, in denen mesodermale Fibrillen und Fibrocyten zu finden sind. In manchen Astrocytomen sind im gesamten Tumorgewebe weite extracelluläre Räume vorhanden.
Allerdings müßte hier die Unreife der Endothelzellen und der Gliazellen bei jungen Tieren wie auch bei Hirntumoren in Rechnung gestellt werden.
Es ist bekannt, daß sowohl bei jungen Tieren wie auch bei Hirntumoren die Permeabilität der Hirncapillaren höher ist als bei erwachsenen Tieren. Vom morphologischen Standpunkt jedoch bestehen in den Voraussetzungen der erhöhten Permeabilität bei jungen Tieren einerseits und bei Hirntumoren andererseits deutliche Unterschiede.
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This study was made possible by a grant from the Rockfeller Foundation GAMNS 59117.
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Tani, E., Ishii, S. Ontogenic studies on the rat brain capillaries in relation to the human brain tumor vessels. Acta Neuropathol 2, 253–270 (1963). https://doi.org/10.1007/BF00686419
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DOI: https://doi.org/10.1007/BF00686419