Summary
Folliculo-stellate (FS) cells were studied in 102 human pituitary adenomas by immunohistochemical techniques using antibodies to S-100 protein and intermediate filaments protein. In most pituitary adenomas there were few S-100-positive cells, in contrast, numerous FS cells were found in four of the 54 cases of non-functioning adenomas. Among glial fibrillary acidic protein (GFAP), keratin and vimentin, FS cells showed greatest affinity to vimentin. Stains for desmin or neurofilaments were always negative. Counterstains with GFAP and keratin could demonstrate a small number of double-labelled cells, but mainly disclosed two types of FS cells positive for either GFAP or keratin. Accordingly, FS cells were grossly subdivided into two types: GFAP-positive cells which might be neuroectodermal or glial in origin and keratin-positive cells which might be oral ectodermal or derive from the Rathke's pouch.
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References
Bergland RM, Torack RM (1969) An ultrastructural study of follicular cells in the human anterior pituitary. Am J Pathol 57:273–286
Budka H (1986) Non-glial specificities of immunocytochemistry for the glial fibrillary acidic protein (GFAP). Acta Neuropathol (Berl) 72:43–54
Caselitz J, Osborn M, Seifert G, Weber K (1981) Intermediate-sized proteins (perkeratin, vimentin, desmin) in the normal parotid gland tumours: immunofluorescence study. Virchows Arch [A] 393:273–286
Cocchia D, Michetti F, Donato R (1981) Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin. Nature 294:85–87
Farquhar MG (1975) Corticotrophs of the rat adenohypophysis as revealed by electron microscopy. Anat Rec 127:291
Forbes MS (1972) Fine structure of the stellate cells in the pars distalis of the lizardAnolis carolinensis. J Morphol 136:227–246
Franko MC, Gibbs CJ Jr, Rhoades DA, Gajdusek DC (1987) Monoclonal antibody analysis of keratin expression in the central nervous system. Neurobiology 84:3482–3485
Fukuda (1973) Agranular stellate cells (so-called follicular cells) in human fetal and adult adenohypophysis and in pituitary adenoma. Virchows Arch [A] 359:19–30
Griod C, Lhéritier M (1981) Ultrastructure des cellules folliculo-srellaires de la pars distalis de l'hypophyse chez le Spermophile (Citellus variegatus Erxleben), le Graphiure (Graphiurus murinus Desmaret), et le Hérisson (Erinaceus europaeus Linnaeus). Gen Comp Endocrinol 43:105–122
Höfler H, Walter GF, Denk H (1984) Immunohistochemistry of folliculo-stellate cells in normal human adenohypophyses and in pituitary adenomas. Acta Neuropathol (Berl) 65:35–40
Höfler H, Denk H, Walter GF (1984) Immunohistochemical demonstration of cytokeratins in endocrine cells of the human pituitary gland and in pituitary adenomas. Virchows Arch [A] 404:359–368
Horvath E, Kovasc K, Penz G, Ezrin C (1974) Origin, possible function and the fate of follicular cells in the anterior lobe of the human pituitary. An electron microscopic study. Am J Pathol 77:199–206
Iwaki T, Kondo A, Takeshita I, Nakagaki H, Kitamura K, Tateishi J (1986) Proliferating potential of folliculo-stellate cells in human pituitary adenomas. Immunohistochemical and electron microscopic analysis. Acta Neuropathol (Berl) 71:233–242
Ironside JW, Royds JA, Jefferson AA, Timperley WR (1987) Immunolocalisation of cytokeratins in the normal and neoplastic human pituitary gland. J Neurol Neurosurg Psychiat 50:57–65
Kagayama M (1965) The follicular cell in the pars distalis of the dog pituitary gland: an electron microscopic study. Endocrinology 77:1053–1060
Kurosumi K (1968) Functioning classification of the cell types in the anterior pituitary gland accomplished by electron microscopy. Arch Histol Jpn 29:324–362
Miettinen M, Clark R, Virtanen I (1986) Intermediate filament proteins in choroid plexus and ependyma and their tumors. Am J Pathol 123:231–240
Molin S-O, Rosengren L, Haglid K, Baudier J, Hamberger A (1984) Differential localization of brain-specific S-100 and its subunits in rat salivary glands. J Histochem Cytochem 32:805–814
Moll R, Franke WW, Schiller DL, Geiger B, Krepler R (1982) The catalog of human cytokeratins. Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11–24
Nakajima T, Yamaguchi H, Takahashi K (1980) S-100 protein in folliculo-stellate cells of the rat anterior pituitary lobe. Brain Res 91:523–531
Nakane PK (1968) Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method, a study on pituitary glands of the rat. J Histochem Cytochem 16:557–560
Nakazato Y, Ishizeki J, Takahashi K, Yamaguchi H, Kamei T, Mori T (1982) Localization of S-100 protein and glial fibrillary acidic protein-related antigen in pleomorphic adenoma of the salivary glands. Lab Invest 46:621–626
Shiotani Y (1980) An electron microscopic study on stellate cells in the rabbit adenohypophysis under various endocrine conditions. Cell Tissue Res 213:237–246
Takahashi K, Yamaguchi H, Ishizeki J, Nakajima T, Nakazato Y (1981) Immunohistochemical and immuno-electron microscopic localization of S-100 protein in the interdigitating reticulum cells of the human lymph node. Virchows Arch [B] 37:125–135
Velasco ME, Roesmann U, Gambetti P (1982) The presence of glial fibrillary acidic protein in the human pituitary gland. J Neuropathol Exp Neurol 41:150–163
Vila-Porcile E (1972) Le réseau des cellules folliculo-stellaires et les follicules de l'adénohypophyse du rat (pars distalis). Z Zellforsch 129:328–369
Yagishita S, Itoh Y, Nakazima S, Suzuki N, Hirata K, Yamashita T (1984) Folliculo-stellate cell adenoma of the pituitary. A light and electron microscopic study. Acta Neuropathol (Berl) 62:340–344
Yamada K, Sano M (1960) Electron microscopic observations on the anterior pituitary of the mouse. Okajimas Folia Anat Jpn 34:449–476
Yoshimura F, Soji T, Sato S, Yokoyama M (1977) Development and differentiation of rat pituitary follicular cells under normal and some experimental conditions with special reference to an interpretation of renewal cell system. Endocrinol Jpn 24:435–449
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Tachibana, O., Yamashima, T. Immunohistochemical study of folliculo-stellate cells in humna pituitary adenomas. Acta Neuropathol 76, 458–464 (1988). https://doi.org/10.1007/BF00686384
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DOI: https://doi.org/10.1007/BF00686384