Abstract
The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therapeutic efficacy against human colorectal adenocarcinoma xenografts than against human gastric and lung adenocarcinoma xenografts. SPAC was effective against three of four human colorectal adenocarcinoma xenografts, with efficacy higher than that of 1-β-d-arabinofuranosylcytosine, fluorouracil, cisplatin, doxorubicin, pirarubicin and vindesine sulfate, but lower than that of mitomycin C and cyclophosphamide. These results indicate that SPAC may be useful for induction and/or postoperative chemotherapy against colorectal adenocarcinomas.
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References
Cullinan SA, O'Connell MJ, Moertel CG, Schutt AJ, Hahn RG, Reitemeier RJ, Frytak S, Rubin J (1977) Phase II study of cytosine arabinoside in advanced large bowel cancer. Cancer Treat Rep 61: 1725–1726
Davis HL, Rochlin DB, Weiss AJ, Wilson WL, Andrews NC, Madden R (1974) Cytosine arabinoside (NSC 63878) toxicity and antitumor activity in human solid tumors. Oncology 29: 190–200
Kodama K, Morozumi M, Saitoh K, Kuninaka A, Yoshino H, Saneyoshi M (1989) Antitumor activity and pharmacology of 1-β-D-arabinofuranosylcytosine-5′-stearylphosphate: an orally active derivative of 1-β-D-arabinofuranosylcytosine. Jpn J Cancer Res 80: 679–685
Sato T, Morozumi M, Kodama K, Kuninaka A, Yoshino H (1984) Sensitive radioimmunoassay for cytarabine and uracil arabinoside in plasma. Cancer Treat Rep 68: 1357–1366
Takayama H, Nakagawa Y, Ochiai H, Morozumi M, Esumi Y, Takaichi M, Jin Y, Seki H, Gunji S, Takiie S, Matsuura C, Kouno K (1993) Metabolic fate of YNK01(1). Absorption, distribution, metabolism and excretion after single administration of [14C]YNK01 to rats (in Japanese). Xenobio Metabol Dispos 8: 1229–1239
Wasserman TH, Comis RL, Goldsmith M, Handelsman H, Penta JS, Slavik M, Soper WT, Carter SK (1975) Tabular analysis of the clinical chemotherapy of solid tumors. Cancer Chemother Rep 6: 399–419
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Koga, K., Iizuka, E., Sato, A. et al. Characteristic antitumor activity of cytarabine ocfosfate against human colorectal adenocarcinoma xenografts in nude mice. Cancer Chemother. Pharmacol. 36, 459–462 (1995). https://doi.org/10.1007/BF00685794
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DOI: https://doi.org/10.1007/BF00685794