Summary
Evidence has been presented that alterations occur in brain tumor blood vessels involving the reduction or deletion of important energy-producing as well as energyconsuming processes within the endothelial cell. In the light of these findings the apparent breakdown of the “blood-brain barrier” and the localization in brain tumors of numerous substances which ordinarily do not enter the brain are not necessarily due to a physical break in the structures which compose the blood-brain barrier but may also be the result of the suppression or deletion of some of the more dynamic aspects of that barrier.
It is also noted that these alterations in enzymes may occur prior to obvious morphological changes in vessels. These observations suggest that some of the morphology of a given glioma may be a trophic response to environmental changes resulting from functional alterations in local vessels.
Zusammenfassung
Es werden Befunde vorgelegt, wonach in Hirntumorgefäßen Veränderungen auftreten, welche die Reduktion und den Verlust wichtiger energieproduzierender und energieverbrauchender Prozesse in der Endothelzelle bedingen. Aufgrund dieser Befunde erscheint der offensichtliche Zusammenbruch der “Blut-Hirnschranke” und die Lokalisation zahlreicher Substanzen in Hirntumoren, die üblicherweise in das Gehirn nicht eindringen, nicht unbedingt durch eine morphologische Desintegration der die BHS bildenden Strukturen bedingt, sondern könnte auch die Folge der Hemmung oder des Verlustes einer oder mehrerer dynamischer Wirkungskomponenten dieser Barriere sein.
Es wird auch festgestellt, daß diese Enzymveränderungen vor augenfälligen morphologischen Gefäßveränderungen auftreten können. Diese Befunde weisen darauf hin, daß einige morphologische Merkmale von Gliomen eine trophische Reaktion auf Veränderungen des umgebenden Gewebes infolge funktioneller Störungen der lokalen Gefäße sein könnten.
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Supported by a research grant from National Institutes of Health.
Included in a special bound volume presented toDr. A. Eabl Walker on the occasion of his Sixtieth Birthday Celebration at The Johns Hopkins Hospital, April 7 and 8, 1967
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O'Connor, J.S., Laws, E.R. Changes in histochemical staining of brain tumor blood vessels associated with increasing malignancy. Acta Neuropathol 14, 161–173 (1969). https://doi.org/10.1007/BF00685296
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DOI: https://doi.org/10.1007/BF00685296