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Über die akuten Veränderungen im Parietalcortex der Ratte nach spitzem Trauma

On acute changes in the parietal cortex of the rat after a stab trauma

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Summary

The parietal cortex of rats was examined by light and electron microscopy 1–120 min after a standardized stab wound (250×450×1800μm, constant stab velocity). The changes in the tissue are already visible qualitatively after 1 min. After about 4 min the expansion of tissue changes stops. 4 zones may be separated. Surrounding the stab canal concentrically they are relatively sharply defined.

Zone I. Stab canal, haemorrhagical or “debris zone”, primary traumatic destroyed zone. The tissue units are here completely destroyed.

Zone II. “Squashed” or “indirectly but irreversibly damaged” zone. It is ca. 80μm wide and contains apart from a protein-rich extracellular fluid almost exclusively swollen cells and cell fragments.

Zone III. Swelling brain or “intracellular peritraumatic edema”. It is ca. 150μm wide and contains mainly dark neurones and swollen astroglia.

Zone IV. Transitional zone of variable width. Here only the perivascular and perineural processes are swollen without changed neurone structure. In all swollen astrocytes mitochondria are altered typically (denser matrix, dilated cristae).

Discussed are: The short latency period, Zone IV, causes of astroglial swelling, origin of extracellular fluid as well as mechanisms which limit the spread of extracellular fluid into Zone II.

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Authors and Affiliations

  1. II. Anatomisches Institut der Freien Universität Berlin, Königin Luise-Straße 15, D-1000, Berlin 33

    W. Noack, J. R. Wolff, F. -H. Güldner & A. Moritz

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  1. W. Noack
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  2. J. R. Wolff
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  3. F. -H. Güldner
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  4. A. Moritz
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Noack, W., Wolff, J.R., Güldner, F.H. et al. Über die akuten Veränderungen im Parietalcortex der Ratte nach spitzem Trauma. Acta Neuropathol 19, 249–264 (1971). https://doi.org/10.1007/BF00684602

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