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Plasma levels and half lives of thioridazine and some of its metabolites

I. High doses in young acute schizophrenics

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Summary

Plasma levels of thioridazine and four of its metabolites were determined in a series of fifteen young acute schizophrenics. Consistent individually different metabolic patterns were detected in a group of patients who had the same value for the sum of thioridazine plus metabolites. The apparent volume of distribution and half life were calculated. Clinical evolution tended to correlate best with the level of mesoridazine.

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Authors and Affiliations

  1. Department of Psychiatry, University of Ghent, Ghent, Belgium

    F. A. J. Vanderheeren

  2. Psychiatric Clinic, Delft, Netherlands

    R. G. Muusze

Authors
  1. F. A. J. Vanderheeren
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  2. R. G. Muusze
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Vanderheeren, F.A.J., Muusze, R.G. Plasma levels and half lives of thioridazine and some of its metabolites. Eur J Clin Pharmacol 11, 135–140 (1977). https://doi.org/10.1007/BF00562905

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  • DOI: https://doi.org/10.1007/BF00562905

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