Summary
Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of the pharmacokinetic parameters derived from these profiles were not significantly different between young subjects, elderly subjects and subjects with alcoholic liver disease. Individual plasma albumin concentrations provided a better index of the unbound plasma salicylate clearances and salicylate plasma protein binding than the age of the subject or the presence of alcoholic liver disease. Highest unbound plasma salicylate concentrations were found in subjects with the lowest plasma albumin concentrations.
Similar content being viewed by others
References
Rowland M, Riegelman S, Harris PA, Sholkoff SD (1972) Absorption kinetics of aspirin in man following oral administration of an aqueous solution. J Pharm Sci 61: 379–385
Levy G, Tsuchiya T, Amsel P (1972) Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man. Clin Pharmacol Ther 13: 258–268
Furst DE, Tozer TN, Melmon KL (1979) Salicylate clearance, the resultant of protein binding and metabolism. Clin Pharmacol Ther 26: 380–389
Mandelli M, Tognoni G (1980) Monitoring plasma concentrations of salicylate. Clin Pharmacokinet 5: 424–440
Rainsford KD, Ford NLV, Brooks PM, Watson HM (1980) Plasma aspirin esterases in normal individuals, patients with alcoholic liver disease and rheumatoid arthritis: characterization and the importance of the enzymatic components. Eur J Clin Invest 10: 413–420
Boobis S, Brodie MJ (1977) The effects of chronic alcohol ingestion and alcoholic liver disease on drug-protein binding. Br J Clin Pharmacol 4: 629P
Castleden CM, Volans CN, Raymond K (1977) The effect of ageing on drug absorption from the gut. Age Ageing 6: 138–143
Salem SAM, Stevenson IH (1977) Absorption kinetics of aspirin and quinine in elderly subjects. Br J Clin Pharmacol 4: 397P
Cuny G, Royer RJ, Mur JM, Sero JM, Fauer G, Netter P, Maillard A, Penin F (1979) Pharmacokinetics of salicylate in the elderly. Gerontology 25: 49–55
Graham GG, Champion GD, Day RO, Paull PD (1977) Patterns of plasma concentrations and urinary excretion of salicylate in rheumatoid arthritis. Clin Pharmacol Ther 22: 410–420
Rowland M, Riegelman S (1967) Determination of acetylsalicylic acid and salicylic acid in plasma. J Pharm Sci 56: 717–720
Rumble RH, Roberts MS, Wanwimolruk S (1981) Determination of aspirin and its major metabolites in plasma by highperformance liquid chromotography without solvent extraction. J Chromatogr 225: 252–260
Cham BE, Bochner F, Imhoff DM, Johns D, Rowland M (1980) Simultaneous liquid chromatographic quantitation of salicylic acid, salicyluric acid and gentisic acid in urine. Clin Chem 26: 111–114
Pederson PV (1977) Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. J Pharmacokinet Biopharm 5: 513–531
Bochner F, Graham GG, Cham BE, Imhoff DM, Haavisto TM (1981) Salicylate metabolite kinetics after several salicylates. Clin Pharmacol Ther 30: 266–275
Koch PA, Schultz CA, Wills RJ, Hallquist SL, Welling PG (1978) Influence of food and fluid ingestion on aspirin bioavailability. J Pharm Sci 67: 1533–1535
Williams RL, Mamelok RD (1980) Hepatic disease and drug pharmacokinetics. Clin Pharmacokinet 5: 528–547
O'Malley K, Laher M, Cusak B, Kelley JG (1980) Clinical pharmacology and the elderly patient. In: Denham MJ (ed) The Treatment of Medical Problems in the Elderly. MTP Press, Lancaster, pp 1–33
Blaschke TF (1977) Protein binding and kinetics of drugs in liver diseases. Clin Pharmacokinet 2: 32–44
Masotti G, Galenti G, Poggesi L, Abbate R, Nevi Serneri GG (1979) Differential inhibition of prostacyclin production and platelet aggregation by aspirin. Lancet 2: 1213–1216
Sitar DS (1980) Letter to the editor. Gerontology 26: 174–175
Wallace S, Whiting B, Runcie J (1976) Factors affecting drug binding in plasma of elderly subjects. Br J Clin Pharmacol 3: 327–330
Harman AW, Frewin DB, Priestly BG, Alexander CBJ (1979) Impairment of hepatic drug metabolism in alcoholics. Br J Clin Pharmacol 7: 45–48
Brodie BB, Burns JJ, Weiner M (1959) Metabolism of drugs in subjects with Laennec's cirrhosis. J Exp Med 1: 290–292
Slattery JT, Gibaldi M, Koup JR (1980) Prediction of maintenance dose required to attain a desired drug concentration at steady-state from a single determination of concentration after an initial dose. Clin Pharmacokinet 5: 377–385
Levy G, Giacomini KM (1978) Rational aspirin dosage regimens. Clin Pharmacol Ther 23: 247–252
Reynolds RC, Cluff LE (1960) Interaction of serum and so-dium salicylate: changes during acute infection and its influence on pharmacological activity. Bull Johns Hopkins Hosp 107: 278–290
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roberts, M.S., Rumble, R.H., Wanwimolruk, S. et al. Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease. Eur J Clin Pharmacol 25, 253–261 (1983). https://doi.org/10.1007/BF00543800
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00543800