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Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

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Abstract

The problems of curve fitting and modeling in pharmacokinetics are discussed. A new nonlinear regression program FUNFIT, written for interactive time sharing, is presented which should be more reliable than programs based on the Gauss-Newton or other related gradient methods. The new program and the well-established program NONLIN were tested on two linear models using human plasma drug level data. FUNFIT found a substantially better solution than NONLIN in the majority of the cases.

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  1. Peter Veng Pedersen

    Present address: Department of Pharmacy, School of Pharmacy, University of California, 94143, San Francisco, California

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  1. Department of Pharmacy, University of Sydney, 2006, Sydney, N.S.W., Australia

    Peter Veng Pedersen

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  1. Peter Veng Pedersen
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Pedersen, P.V. Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. Journal of Pharmacokinetics and Biopharmaceutics 5, 513–531 (1977). https://doi.org/10.1007/BF01061732

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  • DOI: https://doi.org/10.1007/BF01061732

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