Abstract
A new method for the synthesis of 1-substituted 2-aminobenzimidazoles, which are difficult or impossible to obtain by direct amination with sodium amide, is proposed. The method consists in the action of liquid ammonia on 1-R-3-methoxybenzimidazolium salts. The reaction is accompanied by the addition of the amide ion in the 2 position and elimination of a methoxy group.
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See [1] for Communication 6.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1086–1088, August, 1982.
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Medvedeva, M.M., Pozharskii, A.F. Imidazole derivatives that contain potentially labile groupings attached to the N atom. 7. Synthesis of 1-substituted 2-aminobenzimidazoles by ammonolysis of 1-R-3-methoxybenzimidazolium salts. Chem Heterocycl Compd 18, 830–832 (1982). https://doi.org/10.1007/BF00506589
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DOI: https://doi.org/10.1007/BF00506589