Abstract
Some investigators have used evidence that a drug may induce conditioned taste aversion to dismiss other behavioral effects of the drug as due to general toxicity rather than specific pharmacological action. To test the validity of this position, behaviorally relevant doses of alcohol, chlordiazepoxide, and morphine were studied in an aversive taste conditioning paradigm. Drug injections were paired with exposure to saccharin solution on repeated trials. Each drug produced saccharin aversion at one or more doses. Since comparable doses are known to facilitate rather than impair behavior in some situations, the taste aversion test is insufficient to establish the general behavioral toxicity of particular drug doses.
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References
Bainbridge, J. G.: The effect of psychotropic drugs on food reinforced behavior and food consumption. Psychopharmacologia (Berl.) 12, 204–213 (1970).
Barry, H. III, Miller, N. E.: Comparison of drug effects on approach, avoidance, escape motivation. J. comp. physiol. Psychol. 59, 18–24 (1965).
Cameron, O. G., Appel, J. B.: Conditioned suppression of bar-pressing behavior by stimuli associated with drugs. J. exp. Anal. Behav. 17, 127–137 (1972).
Cappell, H., Herman, C. P.: Alcohol and tension reduction: A review. Quart. J. Stud. Alcohol 33, 33–64 (1972).
Cappell, H., LeBlanc, A. E.: Conditioned aversion to saccharin by single administrations of mescaline and d-amphetamine. Psychopharmacologia (Berl.) 22, 352–356 (1971).
Cicala, G. A., Hartley, D. L.: Drugs and the learning and performance of fear. J. comp. physiol. Psychol. 64, 175–178 (1965).
Duncan, D. B.: Multiple-range and multiple-F tests. Biometrics 11, 1–42 (1955).
Elsmore, T. F., Fletcher, G. V.: δ9-Tetrahydrocannabinol: Aversive effects in rats at high doses. Science 176, 911–912 (1972).
Falk, J. L., Burnidge, G. K.: Fluid intake and punishment-attenuating drugs. Physiol. Behav. 5, 199–202 (1970).
Goldberg, S. R., Hoffmeister, F., Schlichtung, U., Wuttke, W.: Aversive properties of nalorphine and naloxone in morphine-dependent rhesus monkeys. J. Pharmacol. exp. Ther. 179, 268–276 (1971).
Goldberg, S. R., Schuster, C. R.: Conditioned nalorphine-induced abstinence changes: Persistence in post morphine-dependent monkeys. J. exp. Anal. Behav. 14, 33–46 (1970).
Lester, D., Nachman, M., LeMagnen, J.: Aversive conditioning by ethanol in the rat. Quart, J. Stud. Alcohol 31, 578–586 (1970).
Margules, D., Stein, L.: Neuroleptics vs. tranquilizers: Evidence from animal behavior studies of mode and site of action. In: H. Brill, J. O. Cole, P. Deniker, H. Hippius, and P. B. Bradley (Eds.): Neuropsychopharmacology, pp. 108–120. Amsterdam: Excepta Medica Foundation 1967.
Martin, J. C., Ellinwood, G. H., Jr.: Aversion to preferred solutions after methamphetamine injections. Proceedings of the 79th Annual Convention of the American Psychological Association 6, 769–770 (1971).
Nachman, M., Lester, D., LeMagnen, J.: Alcohol aversion in the rat: Behavioral assessment of noxious drug effects. Science 168, 1244–1246 (1970).
Schuster, C. R., Thompson, T.: Self-administration of and behavioral dependence on drugs. Ann. Rev. Pharmacol. 9, 483–502 (1969).
Thompson, T., Trombley, J., Luke, D., Lott, D.: Effects of morphine on behavior maintained by four simple food reinforcement schedules. Psychopharmacologia (Berl.) 17, 182–192 (1970).
Weeks, J. R., Collins, R. J.: Factors affecting voluntary morphine intake in self-maintained addicted rats. Psychopharmacologia (Berl.) 6, 267–279 (1964).
Whitney, G. D., Trost, J. G.: Response disruption following amphetamine self- and programmed administration. In: R. T. Harris, W. M. McIsaac, and C. R. Schuster (Eds.): Drug Dependence, pp. 198–213. Austin: University of Texas Press 1970.
Woods, J. H., Ikomi, F., Winger, G.: The reinforcing property of ethanol. In: M. K. Roach, W. M. McIsaac, and P. J. Creaven (Eds.): Biological aspects of alcohol, pp. 371–388. Austin: University of Texas Press 1971.
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Cappell, H., LeBlanc, A.E. & Endrenyi, L. Aversive conditioning by psychoactive drugs: Effects of morphine, alcohol and chlordiazepoxide. Psychopharmacologia 29, 239–246 (1973). https://doi.org/10.1007/BF00414038
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DOI: https://doi.org/10.1007/BF00414038