Summary
-
1.
Radioactive imipramine was administered by mouth to psychiatric patients and metabolites in urine was studied by total counting, extraction and thin layer chromatography.
-
2.
Some 40 per cent of the radioactive dose administered appeared in the urine during the first 24 hour period; a total of some 70 per cent during the first 72 hour period.
-
3.
Of the administered radioactivity 15 per cent was excreted in the form of non-conjugated metabolites, 35 per cent as conjugated metabolites, 23 per cent as non-extractable.
-
4.
Thin layer chromatography showed 4 unknown metabolites containing considerable amounts of radioactivity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Angst, J.: Antidepressiver Effekt und genetische Faktoren. Arzneimittel-Forsch. 14, Suppl. 496–500 (1964).
—: A clinical analytis of the effects of Tofranil in depressions. Psychopharmacologia (Berl.) 2, 381–407 (1961).
Crammer, J. L., and B. Scott: New metabolites of imipramine. Psychopharmacologia (Berl.) 8, 461–468 (1966).
Fishman, V., and H. Goldenberg: Identification of a new metabolite of imipramine. Proc. Soc. exp. Biol. (N. Y.) 110, 187–190 (1962).
Häfliger, F.: Chemistry of Tofranil. Canad. psychiat. Ass. J. 4, Spec. Suppl. 69–74 (1959).
Haydu, G. G., A. Dhryniotis, and G. P. Quinn: Plasma imipramine level in syndromes of depression. Amer. J. Psychiat. 119, 574–575 (1962).
Hermann, B.: Quantitative Methoden zur Untersuchung des Stoffwechsels von Tofranil. Helv. physiol. pharmacol. Acta 21, 402–408 (1963).
—, u. R. Pulver: Der Stoffwechsel des Psychopharmakons Tofranils. Arch. int. Pharmacodyn. 126, 454–469 (1960).
Im Obersteg, J., u. J. Bäumler: Suicid mit dem Psychopharmacon Tofranil. Arch. Toxicol. 19, 339–344 (1962).
Kuhn, R.: Untersuchung über mögliche Zusammenhänge zwischen Metabolitenausscheidung und Krankheitsverlauf depressiver Zustände unter Imipramin-Medikation. Psychopharmacologia (Berl.) 8, 201–222 (1965).
Pare, C. M. B., L. Rees, and M. J. Sainsbury: Differentation of two genetically specific types of depressions by the response to antidepressants. Lancet 1962 II, 1340–1343.
Pinter, K. G., J. G. Hamilton, and O. N. Miller: Liquid scintillation counting with glass fiber paper. Analyt. Biochem. 5, 458–461 (1963).
Slot, C.: Liquid scintillation counting of non-volatile water-soluble compounds. Scand. J. clin. Lab. Invest. 17, 182–184 (1965).
Stahl, E.: Dünnschicht-Chromatographie. Chemiker-Ztg. 82, 323–386 (1958).
Vidic, E.: Nachweis der renalen Ausscheidungsprodukte toxikologisch wichtiger Arzneistoffe mit Hilfe der Papierchromatographie. Arzneimittel-Forsch. 7, 314–318 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Christiansen, J., Gram, L.F., Kofod, B. et al. Imipramine metabolism in man. Psychopharmacologia 11, 255–264 (1967). https://doi.org/10.1007/BF00405231
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00405231