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Quantitative Determination of Ivabradine and Its N-Demethylated Metabolite in Volunteer Blood and Urine

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Pharmaceutical Chemistry Journal Aims and scope

An HPLC method was developed for quantitative determination and pharmacokinetic analysis of ivabradine and its N-demethylated metabolite using the new internal standard domperidone. The method is highly sensitive and selective and can be used in bioassays. The sample preparation procedure was optimized and did not significantly influence the standard error of the quantitative chromatographic method.

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Authors and Affiliations

  1. Volgograd State Medical University, 1 Pavshchikh Bortsov Sq., Volgograd, 400131, Russia

    L. A. Smirnova, B. E. Tolkachev, A. F. Ryabukha, E. A. Suchkov, K. A. Kuznetsov, O. V. Magnitskaya & V. I. Petrov

  2. Volgograd Medical Research Center, 1 Pavshchikh Bortsov Sq., Volgograd, 400131, Russia

    L. A. Smirnova, B. E. Tolkachev, A. F. Ryabukha, E. A. Suchkov & K. A. Kuznetsov

Authors
  1. L. A. Smirnova
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  2. B. E. Tolkachev
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  3. A. F. Ryabukha
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  4. E. A. Suchkov
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  5. K. A. Kuznetsov
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  6. O. V. Magnitskaya
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  7. V. I. Petrov
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Corresponding author

Correspondence to L. A. Smirnova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 3, pp. 61 – 64, March, 2019.

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Smirnova, L.A., Tolkachev, B.E., Ryabukha, A.F. et al. Quantitative Determination of Ivabradine and Its N-Demethylated Metabolite in Volunteer Blood and Urine. Pharm Chem J 53, 275–278 (2019). https://doi.org/10.1007/s11094-019-01992-3

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  • DOI: https://doi.org/10.1007/s11094-019-01992-3

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