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New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR

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Summary

The metabolism of 5′-deoxy-5-fluorouridine (5′dFUrd), an antitumor fluoropyrimidine, has been investigated in human biofluids (blood, plasma, urine) using a new method: fluorine-19 NMR spectrometry. This method allows direct study of the biological sample and simultaneous identification of all the fluorinated metabolites. In the blood of a patient treated with 5′dFUrd during a 6-h continuous perfusion, we observed unmetabolized 5′dFUrd, 5-fluorouracil, 5,6-dihydrofluorouracil, and another metabolite which has not previously been reported α-fluoro-β-alanine. The two major metabolites in urine are unmetabolized 5′dFUrd and α-fluoroβ-alanine.

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Authors and Affiliations

  1. Laboratoire des IMRCP, ERA CNRS no. 264, 118, route de Narbonne, F-31062, Toulouse Cedex, France

    Marie-Catherine Malet-Martino, Robert Martino, André Lopez, Jean-Pierre Béteille & Maryse Bon

  2. Centre Claudius Regaud, 20-24 rue du Pont Saint-Pierre, F-31052, Toulouse, France

    Jean Bernadou & Jean-Pierre Armand

Authors
  1. Marie-Catherine Malet-Martino
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  2. Robert Martino
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  3. André Lopez
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  4. Jean-Pierre Béteille
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  5. Maryse Bon
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  6. Jean Bernadou
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  7. Jean-Pierre Armand
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Malet-Martino, MC., Martino, R., Lopez, A. et al. New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR. Cancer Chemother. Pharmacol. 13, 31–35 (1984). https://doi.org/10.1007/BF00401443

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  • DOI: https://doi.org/10.1007/BF00401443

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