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Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer β-amyloid deposition

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Abstract

The localization of apolipoprotein E (ApoE) has been examined immunohistochemically in the autopsied brains of middle-aged and old-aged control subjects, with and without amyloid β protein (Aβ) deposits, and of Alzheimer's disease patients. Senile plaques were consistently labeled with ApoE antiserum even in the very early stage of senile plaque formation seen in the fifth decade. In the cerebellar molecular layer, small dots of ApoE immunoreactivity, which were prominent in the Alzheimer's disease subjects, were observed in addition to immunoreactivity in diffuse plaques. ApoE antisera labeled all of the extracellular neurofibrillary tangles (NFT), whereas only a small minority of extracellular NFT were positive for Aβ. A punctate pattern of ApoE immunoreactivity was seen at the media of the meningeal vessels lacking amyloid, when senile plaques were present in the nearby cortex. In the early stage of amyloid angiopathy, the distribution of ApoE immunoreactivity was much more extensive than that of Aβ positivity. These findings suggest that ApoE accumulates in the early stage of senile plaque formation and, furthermore, that ApoE accumulation precedes Aβ deposition in extracellular NFT and amyloid angiopathy.

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Authors and Affiliations

  1. College of Medical Care and Technology, Gunma University, 3-39-22 Showa-machi, 371, Maebashi, Gunma, Japan

    Haruyasu Yamaguchi

  2. Department of Neurology, School of Medicine, Gunma University, Gunma, Japan

    Koji Ishiguro, Takeshi Kawarabayashi, Xiaoyan Sun & Shunsaku Hirai

  3. Department of Pathology, Gunma Cancer Center, Gunma, Japan

    Shiro Sugihara

  4. Department of Pathology, School of Medicine, Gunma University, Gunma, Japan

    Yoichi Nakazato

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  1. Haruyasu Yamaguchi
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Yamaguchi, H., Ishiguro, K., Sugihara, S. et al. Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer β-amyloid deposition. Acta Neuropathol 88, 413–419 (1994). https://doi.org/10.1007/BF00389492

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  • DOI: https://doi.org/10.1007/BF00389492

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