Abstract
By use of Southern blot analyses and low copy number probes, the fine structure of the Q region of the mouse major histocompatibility complex was studied in more detail. With a probe recognizing the even-numbered genes Q4, Q6, and Q8, it was evident that Q4 and/or the regions flanking Q4 are polymorphic, whereas Q6 and Q8, and their flanking regions are nonpolymorphic. Perhaps the most noteworthy finding is that at least two strain haplotypes, H-2 k and H-2 f, possessed extensive deletions in the Q region. The most striking deletion was found in the H-2 f haplotype, where the QI through Q9 genes appear to be missing. Because of these extensive deletions the functional importance of the Q region is questioned.
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Eastman O'Neill, A., Reid, K., Garberi, J.C. et al. Extensive deletions in the Q region of the mouse major histocompatibility complex. Immunogenetics 24, 368–373 (1986). https://doi.org/10.1007/BF00377954
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DOI: https://doi.org/10.1007/BF00377954