Abstract
The transfer of 73As and 125SB to the developing mouse organism was studied in the following ways. a) A diet containing the isotopes was given from the day of the vaginal plug and the radioactivity in uterus, ovaries and different maternal organs was determined 2, 4, and 6 days after initiation of feeding. b) The isotopes were injected i.p. during organogenesis at day 12, and the transfer into the fetus as well as activity in maternal organs were followed for a period of 7 days. c) The radioactive diet was supplied during the entire pregnancy and 15 days thereafter. The radioactivity in the females was followed for 150 days, that in the litter for 50 days. Components of turnover of less than a day, less than a week and several months can be discerned in the adult for both isotopes and transfer to the fetus occurs during organogenesis. Less antimony than arsenic is transferred from food during fetal life. After birth, arsenic as well as antimony are taken up by the newborn via the milk.
Zusammenfassung
Der Übergang von 75As und 125Sb auf den sich entwickelnden Mäuseorganismus wurde in folgender Weise untersucht, a) Mäuse erhielten vom Tag des Vaginalpropfens eine Diät mit beiden Isotopen und wurden 2, 4 und 6 Tage später untersucht. b) Die Isotope wurden am Tag 12 der Schwangerschaft während der Organogenese injiziert und der Übergang in den Föten und die Radioaktivität der mütterlichen Organe bis 7 Tage danach verfolgt. c) Die radioaktive Diät wurde während der ganzen Schwangerschaft und für 15 Tage danach gegeben und die Radioaktivität in den weiblichen Mäusen für 150 Tage, in den Jungen für 50 Tage untersucht. Stoffwechselkomponenten mit Turnoverzeiten von weniger als einem Tag, unter einer Woche und von mehreren Monaten wurden für beide Isotope beobachtet, und beide Isotope gehen auf den Föten über. Mehr Arsen als Antimon wird vom Föten aus der mütterlichen Diät aufgenommen. Nach der Geburt werden beide Isotope über die Milch übertragen.
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Gerber, G.B., Maes, J. & Eykens, B. Transfer of antimony and arsenic to the developing organism. Arch Toxicol 49, 159–168 (1982). https://doi.org/10.1007/BF00332363
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DOI: https://doi.org/10.1007/BF00332363