Abstract
Dithiocarb and (+)-cyanidanol-3 prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1 · 8 × 10−5 M for dithiocarb and 2 · 1 × 10−5 M for (+)-cyanidanol-3.
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Younes, M., Siegers, C.P. Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein. Arch. Toxicol. 45, 61–65 (1980). https://doi.org/10.1007/BF00303296
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DOI: https://doi.org/10.1007/BF00303296