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Inflammatory and non-inflammatory inclusion body myositis

Characterization of the mononuclear cells and expression of the immunoreactive class I Major histocompatibility complex product

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Summary

In ten patients with inclusion body myositis (IBM) five muscular biopsies showed profuse inflammatory exudates and three showed a few scattered inflammatory cells with partial invasion in some muscle fibers. No inflammatory cells were seen in two cases. In all patients, histopathological, histomorphometric and immunocytochemical studies were performed. Immunocytochemistry for the class I and class II major histocompatibility complex gene product (MHC) was performed in all cases and in ten control muscles including: normal muscles [3], dermatomyositis [3], polymyositis [3], scleroderma [1]. In the five cases of IBM with inflammatory exudates, subsets of lymphocytes were analyzed with a panel of monoclonal antibodies against B cells, T4 cells, T8 cells, K and natural killer cells and macrophages. Some muscle fibers expressed class I MHC antigens in the inflammatory cases of IBM. These fibers were near the inflammatory exudates and occasionally showed a partial invasion. No expression of class I MHC was found in normal muscles and in non-inflammatory cases of IBM. The antigen which triggers the mononuclear cells in the inflammatory forms of IBM is probably not the filamentous inclusions in rimmed vacuoles. In other inflammatory myopathies, expression of class I MHC was present on all fibers in polymyositis, only in the perifascicular area in dermatomyositis and in scleroderma. It could be suggested that the term “inclusion body muscle disease” be applied to cases with rimmed vacuoles and “IBM-like” filaments without inflammatory cells.

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References

  1. Arahata K, Engel AG (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. I. Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 16:193–208

    Google Scholar 

  2. Araharata K, Engel AG (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. III. Immunoelectron microscopy aspects of cell-mediated muscle fiber injury. Ann Neurol 19:112–125

    Google Scholar 

  3. Arahata K, Engel AG (1988) Monoclonal antibody analysis of mononuclear cells in myopathies. IV. Cell-mediated cytotoxicity and muscle fiber necrosis. Ann Neurol 23:168–173

    Google Scholar 

  4. Arahata K, Engel AG (1988) Monoclonal antibody analysis of mononuclear cells in myopathies. V. Identification and quantitation of T8 cytotoxic and T8 suppressor cells. Ann Neurol 23:493–499

    Google Scholar 

  5. Borg K, Solders G, Borg J, Edström L, Kristensson K (1988) Neurogenic involvement in distal myopathy (Welander). Abstracts of the 9th International Meeting on Neuromuscular Disease. Marseille, p 54

  6. Brooke MH, Engel WK (1969) The histographic analysis of human muscle biopsies with regard to fiber types. Adult male and female. Neurology 19:221–233

    Google Scholar 

  7. Carpenter S, Karpati G, Heller I, Eisen A (1978) Inclusion body myositis. A distinct variety of idiopathic inflammatory myopathy. Neurology 28:8–17

    Google Scholar 

  8. Carpenter S, Karpati G (1984) Inflammatory myopathies inclusion body myositis. Pathology of skeletal muscle. Churchill Livingstone, Edinburgh, pp 559–571

    Google Scholar 

  9. Chou SM (1986) Inclusion body myositis. A chronic persistent mumps myositis. Hum Pathol 17:765–777

    Google Scholar 

  10. Cole AJ, Kuzniecky R, Karpati G, Carpenter S, Andermann E, Andermann F (1988) Familial myopathy with changes resembling inclusion body myositis and periventricular leucoencephalopathy: a new syndrome. Brain 111:1025–1037

    Google Scholar 

  11. Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984) The detailed distribution of HLA A, B, C antigens in normal human organs. Transplantation 38:287–292

    Google Scholar 

  12. Dubowitz V, Brooke MH (1973) Muscle biopsy: a modern approach. Saunders, London, pp 20–23

    Google Scholar 

  13. Eisen A, Berry K, Gibson G (1983) Inclusion body myositis (IBM). Myopathy or neuropathy? Neurology 33:1109–1114

    Google Scholar 

  14. Engel AG, Arahata K (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. II. Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol 16:209–215

    Google Scholar 

  15. Figarella-Branger D, Pellissier JF, Serratrice G, Pouget J, Bianco N (1989) Etude immunocytochimique des formes inflammatoires de myopathies facio-scapulo-humérales et corrélation avec d'autres myosites. Ann Pathol 9:100–108

    Google Scholar 

  16. Flyer DC, Burakoff SJ, Faller DV (1985) Retrovirus induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes. J Immunol 135:2287–2292

    Google Scholar 

  17. Fukuhara N, Kumamoto T, Tsubaki T (1980) Rimmed vacuoles. Acta Neuropathol (Berl) 51:229–235

    Google Scholar 

  18. Fukuhara N, Kumamoto T, Tsubaki T, Mayuzumi T, Nitta H (1982) Oculopharyngeal muscular dystrophy and distal myopathy. Acta Neurol Scand 65:458–467

    Google Scholar 

  19. Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 29:577–580

    Google Scholar 

  20. Isenberg DA, Rowe S, Shearer R, Novick D, Beverley PCL (1986) Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy. Clin Exp Immunol 63:450–458

    Google Scholar 

  21. Julien J, Vital C, Vallat JM, Lagueny A, Sapina D (1982) Inclusion body myositis clinical biological and ultrastructural study. J Neurol Sci 55:15–24

    Google Scholar 

  22. Karpati G, Pouliot Y, Carpenter S (1988) Expression of immunoreactive major histocompatibility complex products in human skeletal muscles. Ann Neurol 23:64–72

    Google Scholar 

  23. Ketelsen UP, Beckmann R, Zimmermann H, Sauer M (1977) Inclusion body myositis. A “slow-virus” infection of skeletal musculature? Klin Wochenschr 55:1063–1066

    Google Scholar 

  24. Kumamoto T, Fukuhara N, Nagashimo M, Kando T, Wakabayashi M (1982) Distal myopathy: histochemical and ultrastructural studies. Arch Neurol 39:367–371

    Google Scholar 

  25. Lotz BP, Engel AG, Nishino H, Stevens JC, Litchy WJ (1989) Inclusion body myositis. Observations in 40 patients. Brain 112:727–747

    Google Scholar 

  26. McDouall RM, Dunn MJ, Dubowitz V (1989) Expression of class I and class II MHC antigens in neuromuscular diseases. J Neurol Sci 89:213–226

    Google Scholar 

  27. Matsubara S, Tanabe H (1982) Hereditary distal myopathy with filamentous inclusions. Acta Neurol Scand 65:363–368

    Google Scholar 

  28. Nishino H, Engel AG, Rima BK (1989) The mumps virus hypothesis of inclusion body myositis. Ann Neurol 25:260–264

    Google Scholar 

  29. Nonaka I, Sunohara N, Ishiura S, Satoyoshi E (1981) Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation. J Neurol Sci 51:141–155

    Google Scholar 

  30. Nonaka I, Sunohara N, Satoyoshi E, Terasawa K, Yonemoto K (1985) Autonomal recessive distal muscular dystrophy: a comparative study with distal myopathy with rimmed vacuole formation. Ann Neurol 17:51–59

    Google Scholar 

  31. Ringel SP, Kenny CE, Neville HE, Giorn OR, Carry MR (1987) Spectrum of inclusion body myositis. Arch Neurol 44:1154–1157

    Google Scholar 

  32. Rosa F, Hatat D, Abadie A, Fellous M (1985) Regulation of histocompatibility antigens by interferon. Ann Inst Pasteur Immunol 136:103–119

    Google Scholar 

  33. Sawchak JA, Kula RW, Sher JH, Shafiq SA, Clark LM (1983) Clinicopathologic investigations in patients with inclusion body myositis. Neurology 33 [Suppl 2]:237

    Google Scholar 

  34. Schwartz RH (1985) T lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol 3:237–261

    Google Scholar 

  35. Serratrice G, Pellissier JF (1987) Myopathies oculaires. Etude nosologique de 49 cas. Presse Med 16:1969–1974

    Google Scholar 

  36. Serratrice G, Pellissier JF, Pouget J, Figarella-Branger D (1989) Formes cliniques des myosites a inclusions: 12 cas. Rev Neurol (Paris) 145:781–788

    Google Scholar 

  37. Smith T, Chad D (1984) Intranuclear inclusions in oculopharyngeal dystrophy. Muscle Nerve 7:339–341

    Google Scholar 

  38. Yunis EJ, Samaha FJ (1971) Inclusion body myositis. Lab Invest 25:240–248

    Google Scholar 

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Authors and Affiliations

  1. Faculté de Médecine Timone, Laboratoire de Neuropathologie, 27 Blv Jean Moulin, F-13385, Marseille Cedex 5, France

    D. Figarella-Branger, J. F. Pellissier, N. Bianco, B. Devictor & M. Toga

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  1. D. Figarella-Branger
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  2. J. F. Pellissier
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  3. N. Bianco
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  4. B. Devictor
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  5. M. Toga
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Figarella-Branger, D., Pellissier, J.F., Bianco, N. et al. Inflammatory and non-inflammatory inclusion body myositis. Acta Neuropathol 79, 528–536 (1990). https://doi.org/10.1007/BF00296113

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  • DOI: https://doi.org/10.1007/BF00296113

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