Summary
Clinical findings suggested an inherited tendency to pressure palsies, but in this case without a family history. This was confirmed pathologically by the identification of a tomaculous neuropathy showing some atypical features including the presence of uncompacted lamellae in a high proportion of fibres.
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References
Behse F, Buchthal F, Carlsen F, Knappeis GG (1972) Hereditary neuropathy with liability to pressure palsies — Electrophysiological and histopathological aspects. Brain 95:777–794
Debruyne J, Dehaene I, Martin JJ (1980) Hereditary pressuresensitive neuropathy. J Neurol Sci 47:385–394
Gabreëls-Festen AAWM, Joosten EMG, Gabreëls FJM, Stegeman DF, Vos AJM, Busch HFM (1990) Congenital demyelinating motor and sensory neuropathy with focally folded myelin sheaths. Brain 113:1629–1643
Herlicoviez D, Lechevalier B, L'Hirondel J, Coquerel G, Lucas P (1979) Recurrent familial neuropathy due to compression. Rev Neurol (Paris) 135:541–556
Jacobs JM, Love S (1985) Qualitative and quantitative morphology of human sural nerve at different ages. Brain 108:897–924
Jacobs JM, Scadding JW (1990) Morphological changes in IgM paraproteinemic neuropathy. Acta Neuropathol 80:77–84
Madrid R, Bradley WG (1975) The pathology of neuropathies with focal thickening of the myelin sheath (tomaculous neuropathy). J Neurol Sci 25:415–448
Meier C, Moll C (1982) Hereditary neuropathy with liability to pressure palsies. Report of two families and review of the literature. J Neurol 228:73–95
Ohnishi A, Hirano A (1981) Uncompacted myelin lamellae in dysglobulinemic neuropathy. J Neurol Sci 51–131–140
Pellissier JF, Pouget J, de Victor B, Serratrice G, Toga M (1987) Tomaculous neuropathy. A histopathological study and electroclinical correlates in 10 cases. Rev Neurol (Paris) 143:263–278
Rebai T, Mhiri C, Heine P, Charfi H, Meyrignac C, Gherardi R (1989) Focal myelin thickenings in a peripheral neuropathy associated with IgM monoclonal gammopathy. Acta Neuropathol 79:226–232
Trockel U, Schröder JM, Reiners KH, Toyka KV, Goerz G, Freund H-J (1983) Multiple exercise-related mononeuropathy with abdominal colic. J Neurol Sci 60:431–442
Vital C, Brechenmacher C, Reiffers J, Lagueny A, Massonnat R, Julien J, Broustet A, Mouton L (1983) Uncompacted lamellae in two cases of peripheral neuropathy. Acta Neuropathol (Berl) 60:252–256
Vital C, Pautrizel B, Lagueny A, Bergouignan FX, David B, Loiseau P (1985) Hypermyelinisation dans un cas de neuropathie périphérique avec gammapathie monoclonale benigne à IgM. Rev Neurol (Paris) 141:729–734
Windebank AJ (1984) Inherited recurrent focal neuropathies. In: Dyck, PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral neuropathy. WB Saunders, Philadelphia, pp 1656–1679
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Jacobs, J.M., Gregory, R. Uncompacted lamellae as a feature of tomaculous neuropathy. Acta Neuropathol 83, 87–91 (1991). https://doi.org/10.1007/BF00294435
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DOI: https://doi.org/10.1007/BF00294435