Summary
Three patients have been detected because of abnormal phenotypes. Balanced chromosome rearrangements were found in their karyotypes, and in one of the parents in each case.
In these three families the association of an abnormal phenotype and a balanced chromosome rearrangement may either be a chance happening or be induced by a submicroscopic loss of chromosome material, for which different position effects may be responsible, according to the case in question.
These observations prompt us to ask what decision should be made relative to termination of pregnancy if such a rearrangement is found in amniotic cells in a family with a previous abnormal child.
Similar content being viewed by others
References
Funderburk, S. J., Spence, M. A., Sparkes, R. S.: Mental retardation associated with balanced chromosome rearrangements. Am. J. Hum. Genet. 29, 136 (1977)
Hemel, J. D., Biervliet, J. P., Grift, P. W. J.: A girl with 46,XX,t(1;15) karyotype. Cytogenetic and clinical observations. Clin. Genet. 8, 213 (1975)
Hustinx, T. W. J., Gabreels, F. J. H., Rutten, F. J., Korten, J. J., Scheers, J. M. J. E., Joosten, E. M. J., Gijsbers, T. J. H.: Case report: a mentally retarded child with a translocation involving chromosomes 12 and 19. J. Med. Genet. 12, 207 (1975)
Jacobs, P. A.: Correlation between euploid structural chromosome rearrangements and mental subnormality in humans. Nature 249, 164 (1974)
Jenkins, E. C., Curcuru-Giordano, F. M., Krishna, S. G., Cantarella, J.: De novo occurrence of 46,XX,t(4;13)(q31;q14) in a mentally retarded girl. Ann. Genet. (Paris) 18, 117 (1975)
Jongbloet, P. H., Van Erkelens-Zweis, J. H. J.: Apparently balanced de novo translocations in patients with abnormal phenotypes. Clin. Genet. 12, 188 (1977)
Leonard, C., Hazael-Massieux, P., Bocquet, P., Larget-Piet, C., Boué, J.: Inversion péricentrique Inv.(2)(p11q13) dans des familles non apparentées. Hum. Genet. 28, 121 (1975)
Skovby, F., Nieburr, E.: Presumably balanced translocations involving the same band of chromosome no. 4 found in two mentally retarded, dysmorphic individuals. Ann. Genet. (Paris) 17, 243 (1974)
Stoll, C., Levy, J. M.: Translocation t(3;20)(p14;p12) de novo chez une fillette. Ann. Genet. (Paris) 17, 197 (1974)
Tharapel, A. V., Summitt, R. L., Wilroy, R. S., Martens, P.: Apparently balanced de novo translocations in patients with abnormal phenotypes: report of 6 cases. Clin. Genet. 11, 255 (1977)
Author information
Authors and Affiliations
Additional information
Attachée de recherche à l'I.N.S.E.R.M.
Attachée de recherche au C.N.R.S.
Rights and permissions
About this article
Cite this article
Ayme, S., Mattei, MG., Mattei, J.F. et al. Abnormal childhood phenotypes associated with the same balanced chromosome rearrangements as in the parents. Hum Genet 48, 7–12 (1979). https://doi.org/10.1007/BF00273267
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00273267