Summary
In the canine pancreas alpha and beta adrenergic receptors exist on D cells with α stimulation inhibiting and β stimulation increasing somatostatin release. There are no dopaminergic receptors on D cells. Stimulation of muscarinic receptors causes mild inhibition of somatostatin secretion. Autonomic receptors on the D cell may be physiologically stimulated in vivo via local ganglionic and/or central autonomic drivers.
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Samols, E., Stagner, J.I. & Weir, G.C. Autonomic function and control of pancreatic somatostatin. Diabetologia 20 (Suppl 1), 388–392 (1981). https://doi.org/10.1007/BF00254507
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DOI: https://doi.org/10.1007/BF00254507