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Monosynaptic inhibition of pallidal neurons by axon collaterals of caudato-nigral fibers

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Summary

The effects produced in the entopeduncular nucleus (ENT) by stimulation of the substantia nigra (SN) were studied in cats anesthetized with pentobarbital. SN stimulation evoked positive field potentials localized in ENT and long latency IPSPs in ENT neurons. The IPSP seemed to be produced monosynaptically since 1. it was evoked by single shocks to SN and had a constant shape and latency, 2. there was no temporal facilitation of the second IPSP when two shocks were applied to SN at various intervals, and 3. an IPSP of similar shape, but shorter latency, was evoked from the diencephalic region between SN and ENT. Linear regression analysis of the latency vs. conduction distance for these two IPSPs, mediated by the same fibers, indicated a synaptic delay of less than 0.7 msec and a conduction velocity for these fibers of about 1 m/sec.

Stimulation of the caudate nucleus evoked IPSPs with shapes similar to those evoked from SN; and there was a strong interaction between SN and caudate-evoked IPSPs, suggesting that they were mediated by the same fibers. Acute experiments on cats in which the caudate nucleus had been destroyed 3 to 7 weeks earlier showed that SN stimulation did not evoke positive field potentials in ENT or IPSPs in ENT cells. It was concluded that SN stimulation antidromically activated caudato-nigral fibers that monosynaptically inhibited ENT cells via axon collaterals.

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Authors and Affiliations

  1. The Rockefeller University, New York City, USA

    Mitsuo Yoshida, Aaron Rabin &  Marjorie Anderson

  2. Department of Neurology, Institute of Brain Research University of Tokyo, Hongo, Tokyo, Japan

    Mitsuo Yoshida

  3. Department of Rehabilitation Medicine, University of Washington School of Medicine, 98195, Seattle, Washington, USA

    Marjorie Anderson

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  1. Mitsuo Yoshida
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  2. Aaron Rabin
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  3. Marjorie Anderson
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Yoshida, M., Rabin, A. & Anderson, M. Monosynaptic inhibition of pallidal neurons by axon collaterals of caudato-nigral fibers. Exp Brain Res 15, 333–347 (1972). https://doi.org/10.1007/BF00234122

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  • DOI: https://doi.org/10.1007/BF00234122

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