Skip to main content
SpringerLink
Log in

The induction of microsomal electron transport enzymes

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

Liver endoplasmic reticulum contains an NADPH-dependent electron transport complex where the family of hemeproteins, termed cytochrome P-450, serve as catalysts for the oxidation of a variety of different organic chemicals. The content and inventory of the types of cytochrome P-450 is readily modified following in vivo treatment of animals with ‘inducing agents’ such as barbiturates, steroids and polycyclic hydrocarbons. Recent studies have applied the methods of molecular biology to evaluate changes in the transcription and translation of genomic information occurring concomitant with the initiation of synthesis of various types of cytochrome P-450. The ability to isolate unique cytochrome P-450 proteins and to prepare specific antibodies now permits the study of in vitro translation of mRNA and the preparation of specific cDNAs. The present review summarizes the historic background leading to current concepts of cytochrome P-450 induction and describes recent advances in our knowledge of the regulation of cytochrome P-450 synthesis in the liver.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mason, H. S., North, J. C. and Vanneste, M., 1965. Fed. Proc. 24: 1172–1180.

    Google Scholar 

  2. La Du, B. N., Trousof, N. and Brodie, B. B., 1953. Fed. Proc. 12: 339.

    Google Scholar 

  3. La Du, B. N., Gaudette, L., Trousof, N. and Brodie, B. B., 1955. J. Biol. Chem. 214: 741–752.

    Google Scholar 

  4. Cooper, J. R. and Brodie, B. B., 1954. J. Pharm. Exp. Ther. 110: 12.

    Google Scholar 

  5. Axelrod, J., 1954. J. Pharm. Exp. Ther. 110: 2.

    Google Scholar 

  6. Brodie, B. B., 1956. J. Pharm. Pharmacol. 8: 1–17.

    Google Scholar 

  7. Brown, R. R., Miller, J. A. and Miller, E. C., 1954. J. Biol. Chem. 209: 211–222.

    Google Scholar 

  8. Conney, A. H., Miller, E. C. and Miller, J. A., 1956. Cancer Res. 16: 450–459.

    Google Scholar 

  9. Conney, A. H., Miller, E. C. and Miller, J. A., 1957. J. Biol. Chem. 228: 753–776.

    Google Scholar 

  10. Conney, A. H., Davison, C., Gastel, R. and Burns, J. J., 1960. J. Pharm. Exp. Ther. 130: 1–8.

    Google Scholar 

  11. Remmer, H., 1959. Arch. Exptl. Path. Pharm. 235: 279–290.

    Google Scholar 

  12. Remmer, H. and Merker, H. J., 1965. Ann. New York Acad. Sci. 123: 79–97.

    Google Scholar 

  13. Klingenberg, M., 1958. Arch. Biochem. Biophys. 75: 376–386.

    Google Scholar 

  14. Omura, T. and Sato, R., 1962. J. Biol. Chem. 237: PC1375–1376.

    Google Scholar 

  15. Omura, T. and Sato, R., 1964. J. Biol. Chem. 239: 2370–2378.

    Google Scholar 

  16. Estabrook, R. W., Cooper, D. Y. and Rosenthal, O., 1963. Biochem. Z. 339: 741–755.

    Google Scholar 

  17. Cooper, D. Y., Levine, S., Narasimhulu, S., Rosenthal, O. and Estabrook, R. W., 1965. Science 147: 400–402.

    Google Scholar 

  18. Orrenius, S. and Ernster, L., 1964. Biochem. Biophys. Res. Commun. 16: 60–65.

    Google Scholar 

  19. Conney, A. H., 1967. Pharmacol. Rev. 19: 317–366.

    Google Scholar 

  20. Johnson, E. F., 1980. J. Biol. Chem. 255: 304–309.

    Google Scholar 

  21. Coon, M. J., Black, S. D., Koop, D. R., Morgan, E. T. and Tarr, G. E., 1982. Microsomes, Drug Oxidations and Drug Toxicity (Sato, R. and Kato, R., eds.), pp. 13–23, Japan Scientific Societies Press, Tokyo.

  22. Guengerich, F. P., Wang, P. and Davidson, N. K., 1982. Microsomes, Drug Oxidations and Drug Toxicity (Sato, R. and Kato, R., eds.), pp. 27–34, Japan Scientific Societies Press, Tokyo.

  23. Aoyama, T., Imai, Y. and Sato, R., 1982. Microsomes, Drug Oxidations and Drug Toxicity (Sato, R. and Kato, R., eds.), pp. 83–84, Japan Scientific Societies Press, Tokyo

  24. Ryan, D. E., Thomas, P. E., Reick, L. M. and Levin, W., 1982. Xenobiotica, 12: 727–744.

    Google Scholar 

  25. Lau, P. P. and Strobel, H. W., 1982. J. Biol. Chem. 257: 5257–5262.

    Google Scholar 

  26. Cheng, K.-C. and Schenkman, J. B., 1982. J. Biol. Chem. 257: 2378–2385.

    Google Scholar 

  27. Lu, A. Y. H. and West, S. B., 1979. Pharmacol. Rev. 31: 277–295.

    Google Scholar 

  28. Bresnick, E., 1982. Hepatic Cytochrome P-450 Monooxygenase System (Schenkman, J. B. and Kupfer, D., eds.), pp. 191–207, Pergamon Press, Oxford.

  29. Dehlinger, P. J. and Schimke, R. T., 1972. J. Biol. Chem. 247: 1257–1264.

    Google Scholar 

  30. Rajamanicham, C., Manchanahall, R., Rao, S. and Padmanaban, G., 1975. J. Biol. Chem. 250: 2305–2310.

    Google Scholar 

  31. Haugen, D. A., Coon, M. J. and Nebert, D. W., 1976. J. Biol. Chem. 251: 1817–1827.

    Google Scholar 

  32. Kato, R., Jondorf, W. R., Loeb, L. A., Ben, T. and Gelboin, H. V., 1966. Mol. Pharmacol. 2: 171–186.

    Google Scholar 

  33. Gelboin, H. V., Wortham, J. J. and Wilson, R. G., 1967. Nature 214: 281–283.

    Google Scholar 

  34. Arias, I. M., Doyle, D. and Schimke, R. T., 1969. J. Biol. Chem. 244: 3303–3315.

    Google Scholar 

  35. Jacob, S. T., Scharf, M. B. and Vessel, E. S., 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 704–707.

    Google Scholar 

  36. Whitlock, J. R., Jr. and Gelboin, H. V., 1974. J. Biol. Chem. 249: 2616–2623.

    Google Scholar 

  37. Whitlock, J. R., Jr., Miller, H. and Gelboin, H. V., 1974. J. Cell Biol. 63: 136–145.

    Google Scholar 

  38. Bhat, K. S. and Padmanaban, G., 1978. FEBS Lett. 89: 337–340.

    Google Scholar 

  39. DuBois, R. N. and Waterman, M. R., 1979. Biochem. Biophys. Res. Commun. 90: 150–157.

    Google Scholar 

  40. Bhat, K. S. and Padmanaban, G., 1979. Arch. Biochem. Biophys. 198: 110–116.

    Google Scholar 

  41. Colbert, R. A., Bresnick, E., Levin, W., Ryan, D. E. and Thomas, P. E., 1979. Biochem. Biophys. Res. Commun. 91: 886–891.

    Google Scholar 

  42. Bar-Nun, S., Kreibach, G., Adesnick, M., Alterman, L., Negishi, M. and Sabatini, D. D., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 965–969.

    Google Scholar 

  43. Pickett, C. B., Rosenstein, N. R., Jeter, R. L., Montisano, D. and Cascarno, J., 1980. Biochemistry, Biophysics and Regulation of Cytochrome P-450 (Gustafsson, J.-A., Carlstedt-Duke, J., Mode, A. and Rafter, J., eds.), pp.441–446, Elsevier/North-Holland, Amsterdam.

  44. De Lella, A. G., Roe, B. A. and Steggles, A. W., 1981. Biochem: Biophys. Res. Commun. 98: 628–634.

    Google Scholar 

  45. Nash, K. L., Chiang, J. Y. L. and Steggles, A. W., 1981. Biochem. Biophys. Res. Commun. 100: 1111–1117.

    Google Scholar 

  46. Pickett, C. B., Telakowski-Hopkins, C. A., Bonohue, A. M., Lu, A. Y. H. and Hales, B. F., 1982. Biochem. Biophys. Res. Commun. 104: 611–619.

    Google Scholar 

  47. Phillips, I. R., Shephard, E. A., Mitani, F. and Rabin, B. R., 1981. Biochem. J. 196: 839–851.

    Google Scholar 

  48. Elshourbagy, N. A., Barwick, J. L. and Guzelian, P. S., 1981. J. Biol. Chem. 256: 6060–6068.

    Google Scholar 

  49. Newman, S. L. and Guzelian, P. S., 1982. Proc. Natl. Acad. Acad. Sci. U.S.A. 79: 2922–2926.

    Google Scholar 

  50. Negishi, M. and Nebert, D. W., 1981. J. Biol. Chem. 256: 3085–3091.

    Google Scholar 

  51. Lechner, M. C., Friere, M. T. and Groner, B., 1979. Biochem. Biophys. Res. Commun. 90: 531–536.

    Google Scholar 

  52. Kumar, A. and Padmanaban, G., 1980. J. Biol. Chem. 255: 522–525.

    Google Scholar 

  53. Bresnick, E., Brosseau, M., Levin, W., Reick, L., Ryan, D. E. and Thomas, P. E., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 4083–4087.

    Google Scholar 

  54. DuBois, R. N., John, M. E., Waterman, M. R., West, S. B. and Lu, A. H. Y., 1980. Biochemistry, Biophysics and Regulation of Cytochrome P-450 (Gustafsson, J.-A., Carlstedt-Duke, J., Mode, A. and Rafter, J., eds.), pp. 397–404, Elsevier/North-Holland, Amsterdam.

  55. Haugan, D. A., Armes, L. G., Yasunobu, K. T. and Coon, M. J., 1977. Biochem. Biophys. Res. Commun. 77: 967–973.

    Google Scholar 

  56. Omura, T., 1979. Induction of Drug Metabolism, Symposia Medica Hoechst 14 (Estabrook, R. W. and Lindenlaub, E., eds.), pp. 161–175, Schattauer Verlag, New York.

  57. Fujii-Kuriyama, Y., Taniguchi, T., Mizukami, Y., Sakai, M., Tashiro, T. and Muramatsu, M., 1981. J. Biochem. 89: 1869–1879.

    Google Scholar 

  58. Adesnick, M., Bar-Nun, S., Maschio, F., Zunich, M., Lippman, A. and Bard, E., 1981. J. Biol. Chem. 256: 10340–10345.

    Google Scholar 

  59. Gonzales, F. J. and Kasper, C. B., 1982. J. Biol. Chem. 257: 5962–5968.

    Google Scholar 

  60. Bresnick, E., Levy, J., Hines, R. N., Levin, W. and Thomas, P. E., 1981. Arch. Biochem. Biophys. 212: 501–507.

    Google Scholar 

  61. Negishi, M., Swan, D. C., Enquist, L. W. and Nebert, D. W., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 800–804.

    Google Scholar 

  62. Tuckey, R. H., Nebert, D. W. and Negishi, M., 1981. J. Biol. Chem. 256: 6969–6974.

    Google Scholar 

  63. DuBois, R. N., Simpson, E. R., Kramer, R. E. and Waterman, M. R., 1981. J. Biol. Chem. 256: 7000–7005.

    Google Scholar 

  64. Fujii-Kuriyama, Y., Mizukami, Y., Sogawa, K. and Muramatsu, M., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 2793–2797.

    Google Scholar 

  65. Haniu, M., Armes, L. G., Tanaka, M., Yasunobu, K., Shastry, B. S., Wagner, C. and Gunsalus, I. C., 1982. Biochem. Biophys. Res. Commun. 105: 889–894.

    Google Scholar 

  66. Yuan, P.-M., Ryan, D. E., Levin, W. and Shively, J. E., 1982. Proc. Natl. Acad. Sci. U.S.A., in press.

  67. Norman, R. L., Johnson, E. R. and Muller-Eberhard, U., 1978. J. Biol. Chem. 253: 8640–8647.

    Google Scholar 

  68. Negishi, M. and Nebert, D. W., 1979. J. Biol. Chem. 254: 11015–11023.

    Google Scholar 

  69. Levin, W., Thomas, P. E., Reick, L., Vlasuk, G. P., Ghrayeb, J., Waltz, F. G., Jr. and Ryan, D. E., 1982. Microsomes, Drug Oxidations and Drug Toxicity (Sato, R. and Kato, R., eds.), pp. 345–352, Japan Scientific Societies Press, Tokyo.

  70. Waltz, F. G., Jr., Vlasuk, G. P., Omiescinski, C. J., Bresnick, E., Thomas, P. E., Ryan, D. E. and Levin, W. E., 1982. J. Biol. Chem. 257: 4023–4026.

    Google Scholar 

  71. Fujii-Kuriyama, Y., Mizukami, Y., Kawajisi, K., Suwa, Y., Sogawa, K. and Muramatsu, M., 1982. Cytochrome P-450: Biochemistry, Biophysics and Environmental Implications (Hietanen, E., ed.), Elsevier/ North-Holland, Amsterdam, in press.

  72. Adesnick, M., Rinkin, E., Kumar, A., Lippman, A., Raphael, C. and Atchison, M., 1982. Cytochrome P-450: Biochemistry, Biophysics and Environmental Implications (Hietanen, E., ed.), Elsevier/North-Holland, Amsterdam, in press.

  73. Nakamura, M., Negishi, M., Altreri, M., Chen, Y.-T. and Nebert, D. W., 1982. Eur. J. Biochem., in press.

  74. Nebert, D. W., Negishi, N., Lang, M. A., Hjelmeland, L. M. and Eisen, H. J., 1982. Advances in Genetics 21: 1–52.

    Google Scholar 

  75. Robinson, J. R., Considine, N. and Nebert, D. W., 1974. J. Biol. Chem. 249: 5851–5859.

    Google Scholar 

  76. Poland, A., Glover, E. and Kende, A. S., 1976. J. Biol. Chem. 251: 4936–4946.

    Google Scholar 

  77. Lang, M. A. and Nebert, D. W., 1981. J. Biol. Chem. 256: 12058–12067.

    Google Scholar 

  78. Negishi, M., Fujii-Kuriyama, Y., Tashiro, Y. and Imai, Y., 1976. Biochem. Biophys. Res. Commun. 71: 1153–1160.

    Google Scholar 

  79. Bhat, K. S. and Padmanaban, G., 1978. Biochem. Biophys. Res. Commun. 84: 1–6.

    Google Scholar 

  80. Craft, J. A., Cooper, M. B., Estall, M. R., Rees, D. E. and Rabin, B. R., 1979. Eur. J. Biochem. 96: 379–391.

    Google Scholar 

  81. Sabatini, D. D., Kreibach, G., Morimoto, T. and Adesnick, M., 1982. J. Cell Biol. 92: 1–22.

    Google Scholar 

  82. Gonzales, F. J. and Kasper, C. B., 1980. Biochemistry 19: 1790–1796.

    Google Scholar 

  83. Gonzales, F. J. and Kasper, C. B., 1981. Biochemistry 20: 2292–2298.

    Google Scholar 

  84. Gonzales, F. J. and Kasper, C. B., 1980. Biophys. Res. Commun. 93: 1254–1258.

    Google Scholar 

  85. Pickett, C. B. and Lu, A. Y. H., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 893–897.

    Google Scholar 

  86. Gonzales, F. J. and Kasper, C. B., 1981. J. Biol. Chem. 256: 4697–4700.

    Google Scholar 

  87. Kalinyak, J. E. and Taylor, J. M., 1982. J. Biol. Chem. 257: 523–530.

    Google Scholar 

  88. Pickett, C. B., Donohue, A. M., Lu, A. Y. H. and Hales, B. F., 1982. Arch. Biochem. Biophys. 215: 539–543.

    Google Scholar 

  89. Pickett, C. B., Telakowski-Hopkins, C. A., Donohue, A. M. and Lu, A. Y. H., 1982. Arch. Biochem. Biophys., in press.

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Texas Health Science Center, 75235, Dallas, TX, USA

    Michael R. Waterman & Ronald W. Estabrook

Authors
  1. Michael R. Waterman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald W. Estabrook
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waterman, M.R., Estabrook, R.W. The induction of microsomal electron transport enzymes. Mol Cell Biochem 53, 267–278 (1983). https://doi.org/10.1007/BF00225259

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00225259

Keywords

Search

Navigation