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ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 (ST3GAL2)

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Handbook of Glycosyltransferases and Related Genes

Abstract

ST3Gal-II is a β-galactoside α2,3-sialyltransferase, which transfers sialic acid from CMP-sialic acid (CMP-Sia) to the terminal Gal residues found in glycoconjugates through an α2,3-linkage. Six different cDNAs encoding ST3Gal enzyme have been identified in various higher vertebrates, which correspond to six ST3Gal gene subfamilies (Harduin-Lepers et al. 2005; Takashima 2008; Hashimoto et al. 2009). From amino acid sequence similarities, substrate specificities, and gene structures, these members can be classified into two subfamilies. One subfamily consists of two members, ST3Gal-I (E.C.2.4.99.4) and ST3Gal-II (E.C.2.4.99.4). The recombinant enzymes in this subfamily use exclusively the type III oligosaccharide structure Galβl-3GalNAc-R as an acceptor substrate. The other subfamily consists of ST3Gal-III, ST3Gal-IV, ST3Gal-V, and ST3Gal-VI. The members use the oligosaccharide isomers Galβ1-3/4Glc(NAc)-R as acceptor substrates.

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Author information

Authors and Affiliations

  1. Institute of Glycoscience, Tokai University, 4-1-1 Kitakaname, 259-1292, Hiratsuka, Kanagawa, Japan

    Dr. Shuichi Tsuji

  2. Laboratory of Glycobiology, The Noguchi Institute, 173-0003, Itabashi, Tokyo, Japan

    Dr. Shou Takashima

Authors
  1. Dr. Shuichi Tsuji
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  2. Dr. Shou Takashima
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Corresponding authors

Correspondence to Shuichi Tsuji or Shou Takashima .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Tsuji, S., Takashima, S. (2014). ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 (ST3GAL2). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_143

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