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Biochemistry and Molecular Biology of Fungal Sterols

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Biochemistry and Molecular Biology

Part of the book series: The Mycota ((MYCOTA,volume 3))

Abstract

Sterols are produced via the ubiquitous isoprenoid pathway which also gives rise to an array of products such as the dolichols and ubiquinone, or components of important molecules such as isopentenyl adenine, heme A, and farnesylated proteins (Ras). Although there are major groups of organisms that cannot produce sterols including insects, parasitic nematodes, and pythiaceous fungi, sterols are widely distributed in nature, where they are required for the growth and/or reproduction of essentially all eukaryotic organisms. With few exceptions, prokaryotes cannot synthesize sterols and, except for some mycoplasmas, they are not required for growth or reproduction. Specific sterols tend to be produced as end products and accumulate in the major groups of organisms, e.g., cholesterol in mammals, and sitosterol in many plants along with cholesterol, stigmasterol, and campesterol. Families of algae tend to accumulate specific sterols such as cholesterol in the red algae (Rhodophyceae) and fucosterol in the brown algae (Phaeophyceae), and others have several predominant sterols which may include 24-methyl and 24-ethylcholesterol and cholesterol (Patterson 1991).

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  1. Botany and Microbiology Department, Alabama Agricultural Experiment Station, Auburn University, Auburn, AL, 36849, USA

    J. D. Weete & S. R. Gandhi

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  1. Department of Plant Biology, University of Minnesota, 220 Biological Sciences Center, 55108, Saint Paul, MN, USA

    Robert Brambl

  2. Department of Biochemistry, Ohio State University, 484 West 12th Avenue, 43210-1292, Columbus, OH, USA

    George A. Marzluf

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Weete, J.D., Gandhi, S.R. (1996). Biochemistry and Molecular Biology of Fungal Sterols. In: Brambl, R., Marzluf, G.A. (eds) Biochemistry and Molecular Biology. The Mycota, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10367-8_20

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