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Cytochrome P450 of Fungi: Primary Target for Azole Antifungal Agents

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Current Topics in Medical Mycology

Part of the book series: Current Topics in Medical Mycology ((CT MYCOLOGY,volume 2))

Abstract

Numerous azole compounds have been developed as potent antifungal agents. These compounds inhibit the growth of fungi by disturbing membrane and membrane-bound enzyme systems. Such disturbance is caused by the depletion of ergosterol and the accumulation of 14-methylsterols such as lanosterol, 24-methylene-24,25-dihydrolanosterol, obtusifoliol, and 14-methylfecosterol in the membrane. Ergosterol is synthesized from lanosterol with the 14-methylsterols appearing as intermediates in the metabolic pathway. The azole antifungal agents inhibit the 14a-demethylation of methylsterols. The 14a-demethylation is a cytochrome P450-dependent reaction, and the cytochrome P450 that catalyzes removal of the 14a-methyl group of 14-methylsterols is believed to be the primary target for azole antifungal agents [for a review, see (101)].

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  1. Yuzo Yoshida
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  1. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27514, USA

    Michael R. McGinnis Ph.D.

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© 1988 Springer-Verlag New York Inc.

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Yoshida, Y. (1988). Cytochrome P450 of Fungi: Primary Target for Azole Antifungal Agents. In: McGinnis, M.R. (eds) Current Topics in Medical Mycology. Current Topics in Medical Mycology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3730-3_11

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  • DOI: https://doi.org/10.1007/978-1-4612-3730-3_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8323-2

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