Abstract
Gliomas, which account for almost half of all central nervous system tumors (1), often affect middle-aged individuals and cause severe social problems. In the US approx. 20,000 cases per year are reported. The corresponding figure for Sweden is 300, and in the Federal Republic of Germany the incidence is estimated to 1/10,000. The prognosis for the malignant forms is very bad, and despite surgical excision followed by irradiation and chemotherapy there has not been any significant increase of the surrival time, which is approx. one year. This might be attributed to a number of factors such as the invasive growth, without sharp delimitation from surrounding normal tissue, the great heterogeneity within the same tumor and the lack of knowledge about the biology of the tumors. Monoclonal antibodies to tumor-associated antigens could prove very helpful in increasing our knowledge of the biology of gliomas and in improving diagnosis and therapy. However, the usefulness of such an antibody depends on its specificity, and those produced so far have shown questionable specificity (2).
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References
Russel DC, Rubinstein LJ (eds) (1977) Pathology of tumours of the nervous system. William and Wilkins Co, Baltimore.
Bourdon MA, Coleman RE, Bigner DD (1984) The potential of monoclonal antibodies as carrier of radiation and drugs for immunodetection and therapy of brain tumours, in Prog Exp Tumor Res (eds ML Rosenblum and CB Wilson) Karger AC, Basel 28: 79–101.
Ando S (1983) Gangliosides in the nervous system. Neurochem Int 5: 507–537.
Hakomori S (1984) Tumor-associated carbohydrate antigen. Ann Rev Immunol 2: 103–126.
Hakomori S (1985) Aberrant glycosylation in cancer cell membrane as focused on glycolipids: overview and prespectives. Cancer Res 45: 2405–2414.
Feizi T (1985) Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature 314: 53–57.
Zülch KJ (1979) Histological typing of tumours of the central nervous system. International histological classification of tumours No 21. World Health organization, Geneva.
Fredman P, von Hoist H, Collins VP, Ammar A, Dellheden B, Wahren B, Granholm L, Svennerholm L (1985) Potential ganglioside antigens associated with human gliomas. Neurol Res 8: 123–126.
Seifert H (1966) Über ein weiters hirntumor characteristiches gangliosid. Klin Wochenschr 44: 469–470.
Kostic’ D, Buchheit F (1970) Gangliosides in human brain tumours. Life Sciences 9: 589–596.
Yates AJ, Thompson DK, Baesel CP, Albrightson C, Hart RW (1979) Lipid composition of human neural tumours. J Lipid Res 20: 428–43.
Traylor DT, Hogan EL (1980) Gangliosides of cerebral astrocytomas. J Neurochem 34: 126–131.
Eto S, Shinoda S (1982) Gangliosides and neutral glycosphingolipids in human brain tumors: specificity and their significance. Adv Exp Med Biol 152: 279–290.
Berra B, Gaini SM, Riboni L (1985) Correlation between ganglioside distribution and histological grading of human astrocytoma. 36: 363–366.
Berra B, Riboni L, de Gasperi R, Gaini SM, Ragnotti G (1983) Modification of ganglioside patterns in human meningiomas. J Neurochem 40: 777–782.
Baumann N, Harpin, ML, Turpin JC (1981) Ganglioside content and pattern in tumor tissue of human neuroblastomas. Biomedicine 35: 215–217.
Schengrund C-L, Repman MA, Shochat SJ (1985) Ganglioside composition of human neuroblastomas 56: 2640–2646.
Wu Z-L, Schwartz E, Seeger R, Ladisch S (1986) Expression of GD2 ganglioside by untreated primary human neuroblastomas. Cancer Res 46: 440–443.
Peak JD, Berry PJ, Pennock CA (1986) Abnormal ganglioside in neuroblastoma. Lancet June 14.
Schuby G, Cheresh DA, Varki NM, Yu A, Staffileno LK, Reisfeld RA (1984) Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res 44: 5914–5920.
Ladisch S, Wu Z-L (1985) Detection of a tumour-associated ganglioside in plasma of patients with neuroblastomas. Lancet i 136–138.
Portoukalian J, Zwingelstein G, Doré J-F (1979) Lipid compositon of human malignant melanoma tumors at various levels of malignant growth. Eur J Biochem 94: 19–23.
Månsson J-E, Fredman P, Nilsson O, Lindholm L, Holmgren J, Svennerholm L (1985) Chemical structure of carcinoma ganglioside antigens defined by monoclonal antibody C-50 and some allied gangliosides of human pancreatic adenocarcinoma. Biochim Biophys Acta 834: 110–117.
Hoshino T, Namura K, Wilson CB, Knebel KD, Gray JW (1978) The distribution of nuclear DNA from human brain tumor cells. J Neurosurg 49: 13–21.
Bigner DD, Bigner SH, Pontén J, Westermark B, Mahaley MS, Ruoslahti E, Herschmann E, Eng LF, Wikstrand CJ (1981) Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J Neuropath Exp Neurol 40: 201–229.
Fredman P, Svennerholm L, Wikstrand CJ, Bigner SH, Mark J, Bigner DD (1986) Canglioside in eleven different established human glioma cell lines. Submitted to J Neuropath Exp Neurol.
Holmgen J, Lindblad M, Fredman P, Svennerholm L, Myrvold H (1985) Comparison of receptors for Cholera and Esherichia coli enterotoxins in human intestine. Gastroenterology 89: 27–35.
Manuelidis L, Yu RK, Manuelidis EE (1977) Canglioside content and pattern in human gliomas in culture. Acta Neuropath 38: 129–135.
Poduslo SE, Miller K, Jang Y (1983) Comparison of lipid metabolism in a human glioma cell line, its clone and Oligodendroglia. Cancer Res 43: 1014–1018.
Coulon-Morelec M-J, Buc-Caron M-H (1981) Lipid patterns of embryonal carcinoma cell lines and their derivatives: Changes with differentiation. Dev Biology 83: 278–290.
Liepkalns VA, Icard C, Yates AJ, Thompson DK, Hart, RW (1981) Effects of cell density on lipids of human glioma and fetal neural cells. J Neurochem 36: 1959–1965.
Liepkalns VA, Icard-Liepkalns C, Yates AJ, Mattison S, Siephens RE (1983) Effects of human brain cell culture conditions on C-glucos-amine radioactivity incorporation into gangliosides. J Lipid Res 24: 533–540.
Månsson J-E, Fredman P, Bigner DD, Molin K, Rosengren B, Friedman HS, Svennerholm L (1986) Characterization of new gangliosides of the lactotetraose series in murine xenografts at a human glioma cell line. Febs Lett 201: 109–113.
Fukuda MN, Bothner B, Lloyd K, Rettig WJ, Tiller PR, Dell A (1986) Structures of glycosphinglipids isolated from human embryonal carcinoma cells. J Biol Chem 261: 5145–5153.
Nilsson O, Månsson J-E, Lindholm L, Holmgren J, Svennerholm L (1985) Sialyllactotetraosylceramide a novel ganglioside antigen detected in human carcinomas by a monoclonal antibody. Febs Lett 182: 398–402.
Molin K, Månsson J-E, Fredman P, Svennerholm L (1986) Sialosyllactotetraosylceramide 3′-LM1, a ganglioside of the lactotetraose series isolated from normal human infant brain. Submitted to J Neurochem.
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© 1987 Springer-Verlag Berlin Heidelberg
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Fredman, P. (1987). Glioma-Associated Gangliosides. In: Rahmann, H. (eds) Gangliosides and Modulation of Neuronal Functions. NATO ASI Series, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71932-5_38
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DOI: https://doi.org/10.1007/978-3-642-71932-5_38
Publisher Name: Springer, Berlin, Heidelberg
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