Gangliosides and Modulation of Neuronal Functions

  • Hinrich Rahmann

Part of the NATO ASI Series book series (volume 7)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Fundamentals for Research on Function of Gangliosides

    1. Front Matter
      Pages 1-1
    2. T. Yamakawa
      Pages 3-15
    3. H. Wiegandt
      Pages 37-47
    4. M. Corti, L. Cantù, S. Sonnino
      Pages 101-118
    5. W. Probst, H. Rahmann
      Pages 139-154
    6. S. Ando, H. Waki, K. Kon, Y. Kishimoto
      Pages 167-177
    7. H. Beitinger, W. Probst, H. Rahmann, G. Schwarzmann, D. Möbius
      Pages 183-184
    8. Back Matter
      Pages 187-188
  3. Brain Ganglioside Metabolism

    1. Front Matter
      Pages 189-189
    2. G. Tettamanti, R. Ghidoni, M. Trinchera
      Pages 191-204

About these proceedings

Introduction

The NATO Advanced Research Workshop on "Gangliosides and Modu­ lation of Neuronal Functions" was held at the University of Stutt­ gart-Hohenheim, Federal Republic of Germany, on October 20 - 24, 1986. About 70 participants from 10 countries presented papers on a wide range of topics all concerning the ganglioside theme. The content of the workshop consisted of the following chap­ ters: (1) Fundamentals for research on function of gangliosides; (2) Brain ganglioside metabolism; (3) Cell specific distribution and differentiation-related ex­ pression of brain gangliosides; (4) Gangliosides and neuronal plasticity; (5) Bio-medical potential of exogenous ganglioside application on neuronal function; and (6) Critical assessments on aspects of ganglioside therapy. The aim of the workshop was to sum up and discuss the present knowledge in the respective fields. Despite intensive research on gangliosides ever since Ernst Klenk discovered them in 1936, the biological function of. these amphiphilic, "sphinx-like" glycosphingo­ lipids remains elusive. Over the past few years, several thousands of articles on gangliosides have been published demonstrating very special properties of these glycolipids and their possible in­ volvement in diverse biological phenomena. As far as we know up to the present time, these properties may be due to particular physico-chemical attributes of these compounds, especially in com­ bination with calcium. The results obtained so far have shed light not only on pos­ sible functional roles of gangliosides with regard to cellular induction and organization, but have also unexpectedly opened up VI a whole new field of therapeutic applications for these compounds.

Keywords

Calcium brain cell culture metabolism muscle nervous system neurons nuclear magnetic resonance (NMR) oncogene paper phosphorylation protein receptor synthesis tumor

Editors and affiliations

  • Hinrich Rahmann
    • 1
  1. 1.Zoological InstituteUniversity of Stuttgart-HohenheimStuttgart 70Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71932-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71934-9
  • Online ISBN 978-3-642-71932-5
  • About this book