Skip to main content
SpringerLink
Log in

Antimuscarinic and Ganglion-Blocking Activity of Neuromuscular Blocking Agents

  • Chapter
New Neuromuscular Blocking Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 79))

Abstract

Among the requirements set by anesthesiologists for new neuromuscular blocking agents, high selectivity of the action on end-plate acetylcholine receptors is one of the most important. Unfortunately, the majority of the known neuromuscular blocking agents, in addition to their main action, may also affect other biologic substrates adapted to the interaction with acetylcholine, such as nicotinic and muscarinic receptors of the autonomic nervous system as well as cholinesterases. Neuromuscular blocking agents with such activity can cause various side effects (changes of hemodynamics, heart rate, etc.).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abrachams VC, Hilton SM (1962) Blocking action of decamethonium at different sites in the autonomic nervous system of the cat. Br J Pharmacol 18:194–203

    Google Scholar 

  • Alyautdin RN, Buyanov VV, Fisenko VP, Lemina EYu, Muratov VK, Samoilov DN, Shorr VA (1980) On some properties of a new steroid curare-like compound pipecurium bromide. Arzneimittelforsch 30(I), 2a:355–357

    PubMed  CAS  Google Scholar 

  • Ardamatskaya AN (1957) Surgical experience with succinylcholine (in Russian). In: Ditilin i opyt ego klinicheskogo primeneniya. Armenian SSR Academy of Sciences Publishers, Yerevan, pp 178–181

    Google Scholar 

  • Artusio JF, Murbury BE, Grews MA (1951) A quantitative study of d-tubocurarine, tri-(ethylaminoethoxy)-1,2,3-benzene (Flaxedil) and a series of tri-methyl and dimethyl-ethylammonium compounds in anaesthetized man. Ann NY Acad Sci 54,3:512–527

    Article  PubMed  CAS  Google Scholar 

  • Arunlakshana O, Shild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14:48–58

    CAS  Google Scholar 

  • Baraka A (1967) A comparative study between diallylnortoxiferine and tubocurarine. Br J Anaesth 39:624–629

    Article  PubMed  CAS  Google Scholar 

  • Benfey BG, Yong MS, Belleau B, Melchiorre C (1979) Cardiac muscarinic blocking and atropine blocking effects of tetramine disulfide with α-adrenoreceptor blocking activity. Can J Physiol Pharmacol 57:41–47

    Article  PubMed  CAS  Google Scholar 

  • Bieger D, Lüllmann H, Wassermann O (1968) Über eine akute Anti-Acetylcholin-Wirkung von Hemicholinium No. 3 am Vorhof des Meerschweinschens. Naunyn Schmidebergs Arch Pharmacol 259:386–393

    CAS  Google Scholar 

  • Birdsall NJM, Burgen ASV, Hulme EC, Stockton JM (1981) Gallamine regulates muscarinic receptors in the heart and cerebral cortex. Br J Pharmacol 74:798P

    Google Scholar 

  • Biró K, Kárpáti E (1981) The pharmacology of new short-acting non-depolarizing muscle relaxant steroid (RGH-4201). Arzneimittelforsch 31:1918–1924

    PubMed  Google Scholar 

  • Björklund A, Cegrell L, Flack B, Ritzen M, Rosengren E (1970) Dopamin-containing cells in sympathetic ganglia. Acta Physiol Scand 78:334–338

    Article  PubMed  Google Scholar 

  • Bonta IL, Buckett WR, Lewis JJ, Vargaftig BB (1966) 2β,16β-dipiperidino-5-androstane-3,17β-diol-diacetatedimethobromide (NA-97) a potent neuromuscular blocking steroid. In: Second International Congress of Steroids, Milan. Excerpta Medica, Amsterdam. Abstracts, p 344

    Google Scholar 

  • Bonta IL, Goorissen EM, Derkx FH (1968) Pharmacological interaction between pancuronium bromide and anaesthetics. Eur J Pharmacol 4:83–90

    Article  PubMed  CAS  Google Scholar 

  • Booij LHDJ, Vree TB, Crul JF (1982) Org NC 45: a new steroidal non-depolarizing muscle relaxant. Pharm Weekbl [Sci] 4:1–4

    CAS  Google Scholar 

  • Boros M, Szenohradszky J, Marosi Gy, Toth J (1980) Comparative clinical study of pipecurium bromide and pancuronium bromide. Arzneimittelforsch 30, 2a:389–393

    PubMed  CAS  Google Scholar 

  • Bourne JC, Collier HOS, Somers GF (1952) Succinylcholine (Succinoylcholine): muscle relaxant of short action. Lancet 1:1225–1229

    Article  PubMed  CAS  Google Scholar 

  • Bovet D, DEpierre F, Courvoisier S, Lestrange Y (1949) Recherches sur les poisons curarisants de synthèse. IIme Partie. Ethers phénoliques à fonction ammonium quaternaire. Action du tri-iodoéthylate de tri(diéthylaminoéthoxy)benzène (2559 F). Arch Int Pharmacodyn Ther 80:172–188

    Google Scholar 

  • Bowman WC (1982) Non-relaxant properties of neuromuscular blocking drugs. Br J Anaesth 54:147–160

    Article  PubMed  CAS  Google Scholar 

  • Brittain RT, Tyers MB (1973) The pharmacology of AH 8165: a rapid-acting, short-lasting, competitive neuromuscular blocking drug. Br J Anaesth 45:837–843

    Article  PubMed  CAS  Google Scholar 

  • Brittain RT, Jack D, Tyers MB (1977) Pharmacological and certain chemical properties of AH 10407. An unusually short-acting, competitive neuromuscular blocking drug, and some related compounds. Br J Pharmacol 61:47–55

    PubMed  CAS  Google Scholar 

  • Brown BR, Crout JR (1966) Mechanism of the positive inotropic effect of gallamine on guinea pig heart muscle. Fed Proc 25:472

    Google Scholar 

  • Brown BR, Crout JR (1968) The sympathomimetic effect of gallamine on the heart. Anesthesiology 29:179–180

    Article  Google Scholar 

  • Brown BR, Crout JR (1970) The sympathomimetic effect of gallamine on the heart. J Pharmacol Exp Ther 172:266–273

    PubMed  CAS  Google Scholar 

  • Brown DA (1980) Locus and mechanism of action of ganglion-blocking agents. In: Kharkevich DA (ed) Pharmacology of ganglionic transmission. Springer, Berlin Heidelberg New York, pp 185–235

    Chapter  Google Scholar 

  • Brücke F (1956) Dicholinesters of α,ω-dicarboxylic acids and related substances. Pharmacol Rev 8:265–335

    PubMed  Google Scholar 

  • Buckett WR, Saxena PR (1969) The pharmacology of dacuronium bromide — a new short-acting neuromuscular blocking drug of non-depolarizing type. In: Proceedings of the 4th International congress of pharmacology, Basel, 14–18 July, p 420

    Google Scholar 

  • Buckett WR, Marjoribanks CEB, Marwick FA, Morton MB (1968) The pharmacology of pancuronium bromide (Org NA97), a new potent steroidal neuromuscular blocking agent. Br J Pharmacol 32:671–682

    CAS  Google Scholar 

  • Bülbring E, Depierre F (1949) The action of synthetic curarizing compounds on skeletal muscle and sympathetic ganglia, both normal and denervated. Br J Pharmacol 4:22–32

    Google Scholar 

  • Bunatyan AA, Mikheev VI (1980) Clinical experience with new steroid muscle relaxant: pipecurium bromide. Arzneimittelforsch 30, 2a:383–385

    Google Scholar 

  • Burstein CL, Jackson A, Bishop HF, Rovenstine EA (1950) Curare in the management of autonomic reflexes. Anesthesiology 11:409–421

    Article  PubMed  CAS  Google Scholar 

  • Butaev BM (1953) Pharmacological study of paramionum, a new synthetic curare-like agent (in Russian). Cand Med Sci Thesis, Leningrad

    Google Scholar 

  • Chappie DJ, Enderby DH, Hughes R, Payne JP (1976) Neuromuscular and cardiovascular studies with dimethyl tubocurarine in anaesthetized cats, rhesus monkeys and man. Br J Pharmacol 56:354P–355P

    Google Scholar 

  • Clark AL, Mitchelson F (1976) The inhibitory effect of gallamine on muscarinic receptors. Br J Pharmacol 58:323–331

    PubMed  CAS  Google Scholar 

  • Coleman AJ, Downing JW, Leary WP, Moyes DG, Styles M (1972) The immediate cardiovascular effects of pancuronium, alcuronium, and tubocurarine in man. Anaesthesia 27:415–422

    Article  PubMed  CAS  Google Scholar 

  • Coleman AJ, O’Brien A, Downing JW, Jeal DE, Moyes DG, Leary WP (1973) AH 8165: a new non-depolarizing muscle relaxant. Anaesthesia 28:262–267

    Article  PubMed  CAS  Google Scholar 

  • Collier HOJ, Hall RA (1950) Pharmacology of d-OO-dimethyl tubocurarine iodide in relation to its clinical use. Br Med J I:1293–1295

    Google Scholar 

  • Crul JF, Booij LHDJ (1980) First clinical experiences with Org NC 45. Br J Anaesth 52, Suppl 1:49S–52S

    Article  PubMed  Google Scholar 

  • Danilov AF, Mikhelson MYa, Rybolovlev RS (1957) Pharmacological properties of succinylcholine and clinical experience with it (in Russian). In: Ditilin i opyt ego klinicheskogo primeneniya. Armenian SSR Academy of Sciences Publishers, Yerevan, pp 92–107

    Google Scholar 

  • Danilov AF, Malygin W, Starshinova LA, Khromov-Borisov NV, Torf SF, Cherepanova VP (1979) Tercuronium — a new nondepolarizing muscle relaxant with high activity and selectivity of the effect (in Russian). Farmakol Toksikol 5:478–481

    Google Scholar 

  • Darbinyan TM, Saliev RSh, Shloznikov BM, Saakyan ES (1980) Haemodynamics during various kinds of combined induction anaesthesia using antidepolarizing muscle relaxants for tracheal intubation (in Russian). Anesteziol Reanimatol 5:7–11

    Google Scholar 

  • Degtyareva LG, Mikhelson VA (1964) Clinical experience with domestic neuromuscular blocking agent qualidil (in Russian). Eksp Khir Anesteziol 6:88–91

    Google Scholar 

  • Docherty JR, McGrath JC (1978) Sympathomimetic effects of pancuronium bromide on the cardiovascular system of the pithed rat: a comparison with the effects of drugs blocking the neuronal uptake of noradrenaline. Br J Pharmacol 64:589–599

    PubMed  CAS  Google Scholar 

  • Docherty JR, McGrath JC (1980) A comparison of the effects of pancuronium bromide and its monoquaternary analogue, Org NC 45, on autonomic and somatic neurotransmission in the rat. Br J Pharmacol 71:225–233

    PubMed  CAS  Google Scholar 

  • Doughty AG, Wylie WD (1951) An assessment of flaxedil (Gallamine triethiodide; B.P.). Proc R Soc Med 44:375–386

    PubMed  CAS  Google Scholar 

  • Drane SE, Evans MH (1979) The relative vagolytic potencies of six muscle relaxants in the rabbit. J Pharm Pharmacol 31:864–866

    Article  PubMed  CAS  Google Scholar 

  • Durant NN, Bowman WC, Marshall IG (1977) A comparison of the neuromuscular and autonomic blocking activities of (+)-tubocurarine and its N-methyl and O,O,N-trimethyl analogues. Eur J Pharmacol 46:297–302

    Article  PubMed  CAS  Google Scholar 

  • Durant NN, Marshall IG, Savage DS, Nelson DN, Sleigh T, Carlyle IC (1979) The neuromuscular and autonomic blocking activities of pancuronium, Org NC 45 and other pancuronium analogues. J Pharm Pharmacol 31, 12:831–836

    Article  PubMed  CAS  Google Scholar 

  • Eckfeld DK (1959) Curarizing and atropine-like properties of bis-atropinium and bis-scopolaminium compounds. J Pharmacol Exp Ther 126:21–23

    PubMed  CAS  Google Scholar 

  • Eisele JH, Marta JA, Davis HS (1971) Quantitative aspects of the chronotropic and neuromuscular effects of gallamine in anesthetized man. Anesthesiology 35:630–633

    Article  PubMed  CAS  Google Scholar 

  • Elwell LH (1960) Effects of d-tubocurarine on the submandibular salivary gland. Am J Physiol 198:621–624

    PubMed  CAS  Google Scholar 

  • Famewo CE (1981) Clinical trial of fazadinium bromide (fazadon). Can Anaesth Soc J 28:149–152

    Article  PubMed  CAS  Google Scholar 

  • Firsov AA, Zhilis BG, Stazhadze LL (1970) Anesthesiological experience with a neuromuscular blocking agent cyclobutonium (in Russian). In: Kharkevich DA (ed) Novye kurarepodobnye i ganglioblokiruyushchie sredstva (New curare-like and ganglion-blocking agents). Meditsina, Moscow, pp 152–159

    Google Scholar 

  • Flacke W, Gillis RA (1968) Impulse transmission via nicotinic and muscarinic pathways in the stellate ganglion of the dog. J Pharmacol Exp Ther 163:266–276

    PubMed  CAS  Google Scholar 

  • Foldes FF, Machaj TS, Carberry PC (1954) The use of gallamine triethiodide (Flaxedil) with pentothal-sodium nitrous oxide-oxygen anesthesia in abdominal surgery. Anaesth Analg 33:122–128

    Article  CAS  Google Scholar 

  • Foldes FF, Swerdlow M, Liphschitz E, Hees GR, Shanor SP (1956) Comparison of the respiratory effects of suxamethonium and suxaethonium in man. Anesthesiology 17:559–568

    Article  PubMed  CAS  Google Scholar 

  • Foldes FF, Wolfson B, Sokoll M (1961) The use of toxiferine for the production of surgical relaxation. Anesthesiology 22:93–99

    Article  PubMed  CAS  Google Scholar 

  • Frey R, Seeger R (1961) Experimental and clinical experience with toxiferine (alkaloid of calabash curare). Can Anaesth Soc J 8:99–117

    Article  PubMed  CAS  Google Scholar 

  • Fuder H, Meiser C, Wormstall H, Muscholl E (1981) The effects of several muscarinic antagonists on pre- and postsynaptic receptors in the isolated rabbit heart. Naunyn Schmiedebergs Arch Pharmacol 316:31–37

    Article  PubMed  CAS  Google Scholar 

  • Gandiha A, Marshall IG, Paul D, Singh H (1974) Neuromuscular and other blocking actions of a new series of mono and bis quaternary aza steroids. J Pharm Pharmacol 26:871–877

    Article  PubMed  CAS  Google Scholar 

  • Gandiha A, Marshall IG, Paul D, Rodger IW, Scott W, Singh H (1975) Some actions of chandonium iodide, a new shrot-acting muscle relaxant, in anaesthetized cats and on isolated muscle preparations. Clin Exp Pharmacol Physiol 2:159–170

    Article  PubMed  CAS  Google Scholar 

  • Gardier RW, Ganansia M-F, Delaunois AL, Hamelberg W (1974) Enhancement of ganglionic muscarinic activity by gallamine. Anesthesiology 40:494–497

    Article  PubMed  CAS  Google Scholar 

  • Gardier RV, Tsevdos EJ, Jackson DB (1978) The effect of pancuronium and gallamine on muscarinic transmission in the superior cervical ganglion. J Pharmacol Exp Ther 204:46–53

    PubMed  CAS  Google Scholar 

  • Goat VA, Feldman SA (1971) Action of muscle relaxant drugs on cardiac cholinergic receptors in the isolated rabbit heart. Br J Anaesthesiol 43:203–204

    CAS  Google Scholar 

  • Greengard P, Kebabian JW (1974) Role of cyclic AMP in synaptic transmission in the mammalian peripheral nervous system. Fed Proc 33:1059–1067

    PubMed  CAS  Google Scholar 

  • Gross EG, Cullen SC (1945) The action of curare on the smooth muscle of the small intestine and on the blood pressure. Anesthesiology 6:231–238

    Article  CAS  Google Scholar 

  • Grossman E, Jacobi AM (1974) Hemodynamic interaction between pancuronium and morphine. Anesthesiology 40:299–301

    Article  PubMed  CAS  Google Scholar 

  • Guyton AC, Reeder RC (1950) Quantitative studies on the autonomic actions of curare. J Pharmacol Exp Ther 98:188–194

    PubMed  CAS  Google Scholar 

  • Hald T, Mygind T (1967) Effect of curare on canine micturition. J Urol 97:101–104

    PubMed  CAS  Google Scholar 

  • Harrison GA (1972) The cardiovascular effects and some relaxant properties of four relaxants in patients about to undergo cardiac surgery. Br J Anaesth 44:485–494

    Article  PubMed  CAS  Google Scholar 

  • Hoppe JO, Funnel JE, Lape H (1955) The effects of structural variation in the quaternary nitrogen centers of benzoquinonium chloride upon neuromuscular blocking activity. J Pharmacol Exp Ther 115:106–119

    PubMed  CAS  Google Scholar 

  • Hughes R (1970) Haemodynamic effects of tubocurarine, gallamine, and suxamethonium in dogs. Br J Anaesth 42:928–934

    Article  PubMed  CAS  Google Scholar 

  • Hughes R (1972) Evaluation of the neuromuscular blocking properties and side-effects of the two new isoquinolinium bisquaternary compounds (BW252C64 and BW403C65). Br J Anaesth 44:27–41

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Chappie DJ (1976 a) Effects of non-depolarizing neuromuscular blocking agents on peripheral autonomic mechanisms in cats. Br J Anaesth 48:59–68

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Chappie DJ (1976 b) Cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys. Br J Anaesth 48:847–852

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Chappie DJ (1981) The pharmacology of atracurium: a new competitive neuromuscular blocking agent. Br J Anaesth 53:31–44

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Ingram GS, Payne JP (1976 a) Studies on dimethyltubocurarine in anaesthetized man. Br J Anaesth 48:969–974

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Payne JP, Sugai N (1976 b) Studies on fazadinium bromide. (AH 8165): a new non-depolarizing neuromuscular blocking agent. Can Anaesth Soc J 23:36–47

    Article  PubMed  CAS  Google Scholar 

  • Ivankovich AD, Miletich DJ, Albrecht RF, Zahed B (1975) The effect of pancuronium on myocardial contraction and catecholamine metabolism. J Pharm Pharmacol 27:837–841

    Article  PubMed  CAS  Google Scholar 

  • Johnstone M, Mahmoud AA, Mrozinski RA (1978) Cardiovascular effects of tubocurarine in man. Anaesthesia 33:587–593

    Article  PubMed  CAS  Google Scholar 

  • Kajimoto N (1970) Pharmacology of alloferin (diallyl-bis-nortoxiferine). Acta Sch Med Univ Kyoto 40:291–304

    CAS  Google Scholar 

  • Kárpáti E, Biró K (1980) Pharmacological study of a new competitive neuromuscular blocking steroid, pipecurium bromide. Arzneimittelforsch 30, 2a:346–354

    PubMed  Google Scholar 

  • Kelman GR, Kennedy BR (1971) Cardiovascular effects of pancuronium in man. Br J Anaesth 43:335–338

    Article  PubMed  CAS  Google Scholar 

  • Kennedy BR, Farman JV (1968) Cardiovascular effects of gallamine triethiodide in man. Br J Anaesth 40:773–780

    Article  PubMed  CAS  Google Scholar 

  • Kennedy BR, Kelman GR (1970) Cardiovascular effects of alcuronium in man. Br J Anaesth 42:625–630

    Article  PubMed  CAS  Google Scholar 

  • Kensler CJ, Zirkle CL, Matallana A, Condouris GJ (1954) The selective anticholinergic activity of aliphatic tris-quaternry ammonium compounds. J Pharmacol Exp Ther 112:210–219

    PubMed  CAS  Google Scholar 

  • Kharkevich DA (1956) Alteration of lability of the superior cervical ganglion under the influence of quaternary ammonium bases (in Russian). Byull Eksp Biol Med 10:34–38

    Google Scholar 

  • Kharkevich DA (1957) The effect of cholinolytic agents on the functional lability of the superior cervical ganglion (in Russian). Byull Eksp Biol Med 12:70–76

    Google Scholar 

  • Kharkevich DA (1962) Ganglionarnye sredstva (Ganglionic agents). Medgiz, Moscow

    Google Scholar 

  • Kharkevich DA (1965) On the pharmacological properties of a new curare-like agent anatruxonium (in Russian). Farmakol Toksikol 3:305–309 or (1966) Fed Proc 25:T521–T523

    Google Scholar 

  • Kharkevich DA (1966) On the pharmacological properties of a new curare-like agent anatruxonium (in Russian). Fed Proc 25:T521–T523

    Google Scholar 

  • Kharkevich DA (1966) On the pharmacology of a new nondepolarizing muscle relaxant cyclobutonium (in Russian). Farmakol Toksikol 1:47–53

    Google Scholar 

  • Kharkevich DA (1970 a) On curare-like activity of decadonium diiodide (in Russian). Farmakol Toksikol 4:395–399

    Google Scholar 

  • Kharkevich DA (1970 b) On the pharmacological properties of a new antidepolarizing curare-like agent diadonium diiodide (in Russian). Farmakol Toksikol 5:531–536

    Google Scholar 

  • Kharkevich DA (1970 c) Pharmacology of new antidepolarizing agents — anatruxonium, truxilonium, cyclobutonium and pyrocyclonium (in Russian). In: Kharkevich DA (ed) Novye kurarepodobnye i ganglioblokiruyushchie sredstva (New curare-like and ganglion-blocking agents). Meditsina, Moscow, pp 41–47

    Google Scholar 

  • Kharkevich DA (1973) Curare-like agents (in Russian). In Kharkevich DA (ed) Uspekhi v sozdanii novykh lekarstvennykh sredstv (Progress in the design of new drugs). Meditsina, Moscow, pp 138–187

    Google Scholar 

  • Kharkevich DA (1974) On predominant action of a number of pharmacological agents on cardiac m-cholinoreceptors (in Russian). Farmakol Toksikol 9:94–102

    CAS  Google Scholar 

  • Kharkevich DA (ed) (1983) New neuromuscular blocking agents. Meditsina, Moscow

    Google Scholar 

  • Kharkevich DA, Kravchuk LA (1961) On the pharmacology of a new curare-like agent truxilonium (in Russian). Farmakol Toksikol 3:318–324

    Google Scholar 

  • Kharkevich DA, Shorr VA (1980) Cardiotropic antimuscarinic action of some curare-like agents. Arch Int Pharmacodyn Ther 248:238–250

    PubMed  CAS  Google Scholar 

  • Kharkevich DA, Skoldinov AP, Samoilov DN, Shorr VA (1981) The effects of anticholinergic agents on muscarinic receptors of different localization. In: Pepeu G, Ladinsky H (eds) Cholinergic mechanisms. Phylogenetic aspects, central and peripheral synapses, and clinical significance. Plenum, New York, pp 351–365

    Google Scholar 

  • Kimura KK, Unna K (1950) Curare-like action of decamethylene-bis(atropinium iodide). J Pharmacol Exp Ther 98:286–292

    PubMed  CAS  Google Scholar 

  • Klupp H, Kraupp O, Stormann H, Stumpf Ch (1953) Über die pharmakologischen Eigenschaften einiger Polymethylen-Dicarbaminsäure-bischolinester. Arch Int Pharmacodyn Ther 96:161–182

    PubMed  CAS  Google Scholar 

  • Klusha VE, Kimenis AA, Sokolov GP (1970) The results of pharmacological and clinical study of a new domestic neuromuscular blocking agent dioxonium (in Russian). In: Eksperimentalnaya i klinicheskaya farmakoterapiya, 2 (Experimental and clinical pharmacotherapy). Zinatne, Riga, pp 55–74

    Google Scholar 

  • Kotomina GL (1970) Comparative clinical evaluation of new neuromuscular blocking agents of the group of diphenylcyclobutanedicarboxylic acids’ derivatives (in Russian). In: Kharkevich DA (ed) Novye kurarepodobnye i ganglioblokiruyushchie sredstva (New curare-like and ganglion-blocking agents). Meditsina, Moscow, pp 83–90

    Google Scholar 

  • Kotomina GL, Kharkevich DA (1968) Clinical pharmacological characteristics of a domestic neuromuscular blocking agent anatruxonium (in Russian). Khirurgiya 4:23–28

    Google Scholar 

  • Kraupp O, Klupp H, Stormann H, Stumpf Ch (1954) Cholinesterasehemmungswirkung und neuromuskuläre Wirksamkeit von Bischolin-Polymethylendicarbaminsäureestern. Arch Exp Pathol Pharmakol 222:180–182

    Article  CAS  Google Scholar 

  • Kuhnen-Clausen D (1970) Investigations on the parasympatholytic effect of toxogonin on the guinea-pig isolated ileum. Eur J Pharmacol 9:85–92

    Article  PubMed  CAS  Google Scholar 

  • Lee C, Yang E, Lippmann M (1980) Constrictive effect of pancuronium on capacitance vessels. Br J Anaesth 52:261–263

    Article  PubMed  CAS  Google Scholar 

  • Lee Son S, Waud BE (1977) Potencies of neuromuscular blocking agents at the receptors of atrial pacemaker and the motor end-plate of the guinea-pig. Anestesiology 47:34–36

    Article  Google Scholar 

  • Lee Son S, Waud DR (1978) A vagolytic action of neuromuscular blocking agents at the pacemaker of the isolated guinea pig atrium. Anesthesiology 48:191–194

    Article  Google Scholar 

  • Lee Son S, Waud DR (1980) Effects of non-depolarizing neuromuscular blocking agents on the cardiac vagus nerve in the guinea pig. Br J Anaesth 52:981–987

    Article  Google Scholar 

  • Lee Son S, Waud BE, Waud DR, Phil D (1981) A comparison of neuromuscular blocking and vagolytic effects of Org NC 45 and pancuronium. Anesthesiology 55:12–18

    Article  Google Scholar 

  • Lemina EYu (1978) Farmakologiya novykh kurarepodobnykh sredstv dipironiya i amidoniya (Pharmacology of new curare-like agents dipyronium and amidonium). Cand Med Sci Thesis, Moscow, 1st Medical Institute

    Google Scholar 

  • Leong W, Given JB, Little DM (1962) The clinical use of imbretil. Can Anaesth Soc J 9:312–318

    Article  PubMed  CAS  Google Scholar 

  • Leung E, Mitchelson F (1982) The interaction of pancuronium with cardiac and ileal muscarinic receptors. Eur J Pharmacol 80:1–9

    Article  PubMed  CAS  Google Scholar 

  • Li CK, Mitchelson F (1978) The effect of stercuronium on cardiac muscarinic receptors. Eur J Pharmacol 51:251–259

    Article  PubMed  CAS  Google Scholar 

  • Li CK, Mitchelson F (1980) The selective antimuscarinic action of stercuronium. Br J Pharmacol 70:313–321

    PubMed  CAS  Google Scholar 

  • Libert B, Tosaka T (1970) Dopamine as a synaptic transmitter and modulator in sympathetic ganglia. A different mode of synaptic action. Proc Natl Acad Sci USA 67:667–673

    Article  Google Scholar 

  • Loh L (1970) The cardiovascular effects of pancuronium bromide. Anaesthesia 25:356–363

    Article  PubMed  CAS  Google Scholar 

  • Longnecker DE, Stoleting RK, Morrow AG (1973) Cardiac and peripheral vascular effects of gallamine. Anaesth Analg 52:931–935

    CAS  Google Scholar 

  • Lüllmann H, Ohnesorge FK, Shauwecker G-C, Wassermann O (1969) Inhibition of the actions of carbachol and DFP on guinea pig isolated atria by alkane-bis-ammonium compounds. Eur J Pharmacol 6:241–247

    Article  PubMed  Google Scholar 

  • Macmillan RR, West DM, Williams NE, Calvey TN (1983) Effects of atracurium on neuromuscular transmission. Br J Clin Pharmacol 15:P154–P155

    Google Scholar 

  • Madden J, Mitchelson F (1975) The interaction of hemicholinium-3 (HC-3) with cholinomimetics and atropine. Eur J Pharmacol 32:17–29

    Article  PubMed  CAS  Google Scholar 

  • Marshall IG (1973) The ganglion-blocking and vagolytic actions of three short-acting neuromuscular blocking drugs in the cat. J Pharm Pharmacol 25:530–536

    Article  PubMed  CAS  Google Scholar 

  • Marshall IG (1980) Actions of non-depolatizing neuromuscular blocking agents at cholinoceptors other than at the motor endplate. In: Curares and curarization. Excerpta Medica, Amsterdam, pp 257–274

    Google Scholar 

  • Marshall IG, Paul D, Singh H (1973) The neuromuscular and other blocking actions of 4,17a-dimethyl-4,17a-diaza-d-homo-5a-androstane dimethiodide (HS-342) in the anaesthetized cat. Eur J Pharmacol 22:129–134

    Article  PubMed  CAS  Google Scholar 

  • Marshall IG, Agoston S, Booij LHDJ, Durant NN, Foldes FF (1980) Pharmacology of Org NC 45 compared with other non-depolarizing neuromuscular blocking drugs. Br J Anaesth 52, Suppl 1:11S–19S

    Article  PubMed  CAS  Google Scholar 

  • Marshall IG, Harvey AL, Singh H, Bhardwaj TR, Paul D (1981) The neuromuscular and autonomic blocking effects of azosteroids containing choline or acetylcholine fragments. J Pharm Pharmacol 33:451–457

    Article  PubMed  CAS  Google Scholar 

  • Marshall RJ, Ojewole JAO (1979) Comparison of the autonomic effects of some currently used neuromuscular blocking agents. Br J Pharmacol 66:77–78

    Google Scholar 

  • Marshall RJ, McGrath JC, Miller RD, Docherty JR, Lamar J-C (1980) Comparison of the cardiovascular actions of Org NC 45 with those produced by other non-depolarizing neuromuscular blocking agents in experimental animals. Br J Anaesth 52, Suppl 1:21S–31S

    PubMed  CAS  Google Scholar 

  • Mashkovsky MD, Briskin AI (1952) Pharmacological properties of a new curare-like drug “diplacine” (in Russian). Farmakol Toksikol 5:24–32

    Google Scholar 

  • Mashkovsky MD, Medvedev BA (1960) On the pharmacology of symmetrical bis-quaternary derivatives of 9-methyl-3,9-diazobicyclo-(3,3,1)-nonane (in Russian). Farmakol Toksikol 6:493–499

    Google Scholar 

  • Mashkovsky MD, Sadritdinov F (1962) Curare-like properties of 1,6-di-(3,3-benzylquinuclidyl-1,1)-hexane dichloride (Qualidil) (in Russian). Farmakol Toksikol 6:685–691

    Google Scholar 

  • Matsuki A, Kothary SP, Zsigmond EK (1973) Effects of gallamine on plasma Cortisol and catecholamine levels in man. Can Anaesth Soc J 20:539–545

    Article  PubMed  CAS  Google Scholar 

  • Mautner H, Luisada A (1941) Antagonistic effect of asphyxia to curare paralysis of the vagus nerve. J Pharmacol Exp Ther 72:386–393

    Google Scholar 

  • McCullough LS, Rier CE, Delaunois AL, Gardier RW, Hamelberg W (1970) The effect of d-tubocurarine on spontaneous postganglionic sympathetic activity and histamine release. Anesthesiology 33:328–334

    Article  PubMed  CAS  Google Scholar 

  • McCullough LS, Stone WA, Delaunois AL, Rier CE, Hamelberg W (1972) The effect of dimethyl tubocurarine iodide on cardiovascular parameters, postganglionic sympathetic activity and histamine release. Anaesth Analg 51:554–559

    CAS  Google Scholar 

  • Mcintosh FC, Paton WDM (1949) The liberation of histamine by certain organic bases. J Physiol (Lond) 109:190–219

    Google Scholar 

  • Medvedev BA (1962) Comparative study of neuromuscular blocking and other pharmacological properties of 1,4-bis[9-methyl-3,9-diazabicyclo-(3,3,1)-nonano-3]butane diiodomethylate and dimethylsulphomethylate (in Russian). Farmakol Toksikol 3:320–326

    Google Scholar 

  • Miller RD, Eger EI II, Stevens WC, Gibbons K (1975) Pancuronium-induced tachycardia in relation to alveolar halothane, dose of pancuronium, and prior atropine. Anesthesiology 42:352–355

    Article  PubMed  CAS  Google Scholar 

  • Mitchelson F (1971) Differentiation between the actions of acetylcholine and tetramethylammonium on the isolated taenia of the guinea-pig caecum by hemicholinium-3. Br J Pharmacol 42:43–55

    PubMed  CAS  Google Scholar 

  • Morgenstern C, Splinth G (1965) Untersuchungen über die Ursachen der Gallamintachykardie und ihre antagonistische Beeinflussung durch Beta-Adrenolytica. Anaesthesist 14:298–301

    PubMed  CAS  Google Scholar 

  • Munger WL, Miller RD, Stevens WC (1974) The dependence of d-tubocurarine-induced hypotension on alveolar concentration of halothane, dose of d-tubocurarine, and nitrous oxide. Anesthesiology 40:442–448

    Article  PubMed  CAS  Google Scholar 

  • Murbury BE, Artusio JE, Wescoe WC, Riker WF (1951) The effects of synthetic curarelike compound tri-iodo salt of tris-(triethylaminoethoxy)-1,2,3-benzene (Flaxedil) on the anaesthetized surgical patients. J Pharmacol Exp Ther 103:280–287

    Google Scholar 

  • Mushin WW, Wien R, Mason DFJ, Langston GT (1949) Curare-like action of tri-(diethylaminoethoxy)-benzene triethiodide. Lancet 1:726–728

    Article  PubMed  CAS  Google Scholar 

  • Nana A, Cardan E, Domokos M (1973) Blood catecholamine changes after pancuronium. Acta Anaesth Scand 17:83–87

    Article  PubMed  CAS  Google Scholar 

  • Ostrovsky VYu, Kiselev SO (1980) Anesthesiological experience with diadonium (in Russian). Anesteziol Reanimatol 4:7–10

    Google Scholar 

  • Paton WDM (1949) The pharmacology of curare and curarizing substances. J Pharm Pharmacol 1:273–286

    Article  PubMed  CAS  Google Scholar 

  • Paton WDM (1957) Histamine release by compounds of simple chemical structure. Pharmacol Rev 9:269–328

    PubMed  CAS  Google Scholar 

  • Paton WDM (1959) The effects of muscle relaxants other than muscular relaxation. Anesthesiology 20:453–463

    Article  PubMed  CAS  Google Scholar 

  • Payne JP, Hughes R (1981) Evaluation of atracurium in anaesthetized man. Br J Anaesth 53:45–54

    Article  PubMed  CAS  Google Scholar 

  • Pelikan EW, Unna KR (1952) The functional importance of the quaternary nitrogen atoms in Flaxedil. J Pharmacol Exp Ther 104:354–362

    PubMed  CAS  Google Scholar 

  • Quintana A (1977) Effect of pancuronium bromide on the adrenergic reactivity of the isolated rat vas deferens. Eur J Pharmacol 46:275–277

    Article  PubMed  CAS  Google Scholar 

  • Qvist TF, Lang-Jensen T, Korshin JD, Skovsted P (1980) The cardiovascular effects of pancuronium during halothane and cyclopropane anaesthesia. Acta Anaesth Scand 24:415–418

    Article  PubMed  CAS  Google Scholar 

  • Rathbun FJ, Hamilton JT (1970) Effect of gallamine on cholinergic receptors. Can Anaesth Soc J 17:574–590

    Article  PubMed  CAS  Google Scholar 

  • Riker WF, Wescoe WC (1951) The pharmacology of flaxedil, with observations on certain analogs. Ann NY Acad Sci 54:373–394

    Article  PubMed  CAS  Google Scholar 

  • Saito S, Aviado DM (1963) Pharmacological studies of hexamethylene-bis-carbaminoylcholine (Imbretil) on the cardiovascular and respiratory systems in dogs. Jpn Circ J 27:791–796

    Article  PubMed  CAS  Google Scholar 

  • Salmenperä M, Tammisto T (1980) The use of dioxonium as a neuromuscular blocking agent. Acta Anaesth Scand 24:395–398

    Article  PubMed  Google Scholar 

  • Salt PJ, Barnes PK, Conway CM (1980) Inhibition of neuronal uptake of noradrenaline in the isolated perfused rat heart by pancuronium and its homologues, Org 6368, Org 7268, and NC 45. Br J Anaesth 52:313–317

    Article  PubMed  CAS  Google Scholar 

  • Samoilov DN (1971 a) Chemical structure and cholinolytic activity of bis-quaternary ammonium derivatives of truxillic acids (in Russian). Farmakol Toksikol 4:413–420

    Google Scholar 

  • Samoilov DN (1971 b) On the chemical structure and ganglion blocking activity of truxillic acid derivatives (in Russian). Farmakol Toksikol 5:544–549

    Google Scholar 

  • Savarese JJ (1979) The autonomic margins of safety of metocurine and d-tubocurarine in the cat. Anesthesiology 50:40–46

    Article  PubMed  CAS  Google Scholar 

  • Savarese JJ, Ali HH, Antonio RP (1977) The clinical pharmacology of metocurine: Dimethyltubocurarine revisited. Anesthesiology 47:277–284

    Article  PubMed  CAS  Google Scholar 

  • Saxena PR, Bonta IL (1970) Mechanism of selective cardiac vagolytic action of pancuronium bromide. Specific blockade of cardiac muscarinic receptors. Eur J Pharmacol 11:332–341

    Article  PubMed  CAS  Google Scholar 

  • Segarra Domenech J, Santafe Oroz R, Rodriguez Sasiain JM, Quintana Loyola A, Santafe Oroz J (1976) Pancuronium bromide: An indirect sympathomimetic agent. Br J Anaesth 48:1143–1148

    Article  Google Scholar 

  • Sheth V, Iabuis II (1980) Comparison of cardiovascular effect of pancuronium bromide with d-tubocurarine and gallamine. Indian J Anaesth 28:42–50

    Google Scholar 

  • Shorr VA (1972) On the action of curare-like agents on some acetylcholine effects (in Russian). Farmakol Toksikol 4:426–431

    Google Scholar 

  • Shorr VA (1975) On the peculiarities of action of neuromuscular blocking agents on m-cholinoreceptors of various localizations (in Russian). Farmakol Toksikol 1:38–43

    Google Scholar 

  • Smith G, Proctor DW, Spence AA (1970) A comparison of some cardiovascular effects of tubocurarine and pancuronium in dogs. Br J Anaesth 42:923–927

    Article  PubMed  CAS  Google Scholar 

  • Smith NT, Whitcher CE (1967) Hemodynamic effects of gallamine and tubocurarine administered during halothane anesthesia. JAMA 199:704–708

    Article  PubMed  CAS  Google Scholar 

  • Stenlake JB, Waigh RD, Urwin J, Dewar GH, Hughes R, Chappie DJ (1981 a) Bis-3,4-dihydroisoquinolinium salts as potential neuromuscular blocking agents. Eur J Med Chem 16:503–507

    CAS  Google Scholar 

  • Stenlake JB, Waigh RD, Urwin J, Dewar GH, Hughes R, Chappie DJ (1981 b) Biodegradable neuromuscular blocking agents. Eur J Med Chem 16:508–514

    CAS  Google Scholar 

  • Stenlake JB, Waigh RD, Dewar GH, Hughes R, Chappie DJ, Coker GG (1981 c) Biodegradable neuromuscular blocking agents. Part 4. Atracurium Besylate and related polyalkylene di-esters. Eur J Med Chem 16:515–524

    CAS  Google Scholar 

  • Stoelting RK (1972) The hemodynamic effects of pancuronium and d-tubocurarine in anaesthetized patients. Anesthesiology 36:612–615

    Article  PubMed  CAS  Google Scholar 

  • Stoelting RK (1973) Hemodynamic effects of gallamine during halothane-nitrous oxide anaesthesia. Anesthesiology 39:645–647

    Article  PubMed  CAS  Google Scholar 

  • Stoelting RK, Longnecker DE (1972) Effect of promethazine on hypotension following d-tubocurarine use in anaesthetized patients. Anesth Analg 51:509–516

    PubMed  CAS  Google Scholar 

  • Sugrue MF, Duff N, McIndewar I (1975) On the pharmacology of Org 6368 (2β,16β-dipiperidino-5α-androstan-3α-ol acetate dimethobromide), a new steroidal neuromuscular blocking agent. J Pharm Pharmacol 27:721–727

    Article  PubMed  CAS  Google Scholar 

  • Tammisto T, Welling I (1969) The effect of alcuronium and tubocurarine on blood pressure and heart rate: a clinical comparison. Br J Anaesth 41:317–322

    Article  PubMed  CAS  Google Scholar 

  • Teerapong P, Marshall IG, Harvey AL, Singh H, Paul D, Bhardwaj TR, Ahuja NK (1979) The effects of dihydrochandonium and other chandonium analogues on neuromuscular and autonomic transmission. J Pharm Pharmacol 31:521–528

    PubMed  CAS  Google Scholar 

  • Thesleff E (1952) Succinylcholine iodide. Studies on its pharmacological properties and clinical use. Acta Physiol Scand 27, Suppl 99:103–129

    Article  Google Scholar 

  • Thomas ET (1963) The effect of gallamine triethiodide on blood pressure. Anaesthesia 18:316–323

    Article  PubMed  CAS  Google Scholar 

  • Tomlinson DR (1979) On the mechanism of pancuronium-induced supersensitivity to noradrenaline in rat smooth muscle. Br J Pharmacol 65:473–478

    PubMed  CAS  Google Scholar 

  • Unna KR, Pelikan EW, Macfarlane DW, Cazort RJ, Sadove MS, Nelson JT, Drucker AP (1950 a) Evaluation of curarizing drugs in man. I. Potency, duration of action and effects on vital capacity of d-tubocurarine, dimethyl-d-tubocurarine and decamethylenebis(trimethylammonium bromide). J Pharmacol Exp Ther 98:318–329

    PubMed  CAS  Google Scholar 

  • Unna KR, Pelikan EW, Macfarlane DW, Sadove MS (1950 b) Evaluation of curarizing drugs in man. IV. Tri-(diethylaminoethoxy)-1,2,3-benzene (Flaxedil). J Pharmacol Exp Ther 100:201–209

    PubMed  CAS  Google Scholar 

  • Valdman AV, Ivanova ZN, Kharkevich DA (1955) The effect of diplacine on the transmission in various links of reflex arch (in Russian). Farmakol Toksikol 2:3–11

    Google Scholar 

  • Vercruysse P, Bossuyt P, Hanegreefs G, Verbeuren TJ, Vanhoutte PM (1979) Gallamine and pancuronium inhibit pre- and post-junctional muscarinic receptors in canine saphenous veins. J Pharmacol Exp Ther 209:225–230

    PubMed  CAS  Google Scholar 

  • Volikov AA (1954) Clinical use of domestic curare-like agents during intratracheal gas and ether anaesthesia (in Russian). Vestn Khir 8:10–18

    Google Scholar 

  • Walts LE, Prescott FS (1965) The effects of gallamine on cardiac rhythm during general anesthesia. Anaesth Analg 44:265–269

    CAS  Google Scholar 

  • Waser P, Harbeck P (1959) Erste klinische Anwendung der Calebassenalkaloide Toxiferin I und Curarin I. Anaesthetist 8:193–198

    CAS  Google Scholar 

  • Wong KC, Wyte SR, Martin WE, Crawford EW (1971) Antiarrhythmic effects of skeletal muscle relaxants. Anesthesiology 34:458–462

    Article  PubMed  CAS  Google Scholar 

  • Zyablina TF (1959) The use of diplacine during intrathoracic operations in pulmonary tuberculosis patients (in Russian). Vestn Khir 11:112–116

    Google Scholar 

Download references

Authors
  1. D. A. Kharkevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Shorr
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Academy of Medical Sciences First Medical Institute, 2/6 Pirogovskaya Street, Moscow, II9435, USSR

    Dimitry A. Kharkevich M.D., D. Sc. (Professor and Chairman of the Department of Pharmacology Academician of the USSR) (Professor and Chairman of the Department of Pharmacology Academician of the USSR)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kharkevich, D.A., Shorr, V.A. (1986). Antimuscarinic and Ganglion-Blocking Activity of Neuromuscular Blocking Agents. In: Kharkevich, D.A. (eds) New Neuromuscular Blocking Agents. Handbook of Experimental Pharmacology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70682-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70682-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70684-4

  • Online ISBN: 978-3-642-70682-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation