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New Neuromuscular Blocking Agents

Basic and Applied Aspects

  • Dimitry A. Kharkevich

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 79)

Table of contents

  1. Front Matter
    Pages I-XXIV
  2. Neuromuscular Blocking Agents: General Considerations

  3. The End-Plate Acetylcholine Receptors: Structure and Function

  4. Pharmacodynamics and Pharmacokinetics of Neuromuscular Blocking Agents

  5. On the Relationship Between the Chemical Structure and the Neuromuscular Blocking Activity

    1. Front Matter
      Pages 277-277
    2. M. Riesz, E. Kárpáti, L. Szporny
      Pages 301-322
    3. D. A. Kharkevich, A. P. Skoldinov
      Pages 323-369
    4. M. D. Mashkovsky, L. N. Yakhontov, V. V. Churyukanov
      Pages 371-382
    5. N. V. Khromov-Borisov
      Pages 383-390
    6. M. D. Mashkovsky, V. V. Churyukanov
      Pages 391-397
  6. Preclinical Pharmacology of New Neuromuscular Blocking Drugs

    1. Front Matter
      Pages 399-399
    2. K. Biró, E. Kárpáti, L. Szporny
      Pages 401-417
    3. W. C. Bowman, G. A. Sutherland
      Pages 419-443
    4. D. A. Kharkevich
      Pages 445-471
    5. D. A. Kharkevich
      Pages 473-483
    6. A. F. Danilov
      Pages 485-497
    7. A. A. Ķimenis
      Pages 499-518
    8. M. B. Tyers
      Pages 519-527
    9. R. Hughes
      Pages 529-543
  7. Clinical Pharmacology of New Neuromuscular Blocking Drugs

    1. Front Matter
      Pages 545-545
    2. E. Tassonyi, G. Szabó, L. Vimláti
      Pages 599-616
    3. R. D. Miller
      Pages 617-627
    4. M. B. Tyers
      Pages 629-636
    5. R. Hughes, J. P. Payne
      Pages 637-650
  8. Antagonists of Neuromuscular Blocking Agents (Pharmacology and Clinical Use)

    1. Front Matter
      Pages 651-651
    2. D. S. Paskov
      Pages 653-672
    3. A. Ķimenis
      Pages 673-677
    4. D. S. Paskov, S. Agoston, W. C. Bowman
      Pages 679-717
  9. Back Matter
    Pages 719-744

About this book

Introduction

The problems associated with the pharmacologic and physiologic regulation of neuromuscular transmission and of the morphofunctional organization of neuromuscular junctions have attracted a wide range of investigators. Numerous handbooks, monographs, and reviews are devoted to this subject. At the same time, many fundamental and applied aspects of this trend continue to progress succesfully. In recent years, new experimental and clinical data on the structure and function of neuromuscular junctions have been gained, and new, more perfect neuromuscular blocking agents have been designed. It is these data that the present handbook mainly deals with. A considerable number of chapters have been written by authors from eastern Europe. This was done intentionally since much of their work has previously been published only in their own languages, and is thus inaccessible to most Western readers. This is why some of the data included in the volume are not quite the latest, but they contain fruitful ideas or important results and are of value for further progress in the pharmacology of neuromuscular transmission. Naturally, the methodological level of the investigations differs, depending on when they were carried out. The handbook contains a number of selected chapters on the pharmacology of neuromuscular junctions; they comprise data otherwise insufficiently reviewed or not dealt with at all. They furthermore reflect the up-to-date state of the problem and probable directions of further developments in this field. D. A. KHARKEVICH Contents CHAPTER 1 Neuromuscular Blocking Agents: General Considerations D. A. KHARKEVICH . . . . . . . . . . . . . . . .

Keywords

Acetylcholin Aldehyde Histamin Nicotin Respiration antibiotics metabolism methylation mutagenesis pharmacodynamics pharmacokinetics pharmacology steroids toxicity toxicology

Editors and affiliations

  • Dimitry A. Kharkevich
    • 1
  1. 1.Department of PharmacologyAcademy of Medical Sciences First Medical InstituteMoscowUSSR

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-70682-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-70684-4
  • Online ISBN 978-3-642-70682-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site