Abstract
The energy produced in the brain is used for three general purposes. First, it is used to support transmission of electrical impulses, including events involved in synaptic activity. This work encompasses both the constant repumping of ions that conduct the currents during nervous activity and the synthesis of neurotransmitters and neuromodulators. This obviously requires a great proportion of the energy produced, but transmission is evidently not a vital function for the nerve cell itself. Thus, with marginal degrees of energy failure (e.g. due to hypoxia, ischemia or hypoglycemia), the neuron may become electrically silent and yet recover completely, if an adequate energy state is restored (see Astrup in this book). The structural detection of cellular injury necessitates visible changes, such as altered form, relationships or stainability of cells. It may be assumed with great confidence (though direct evidence is lacking) that the neurons passing the threshold of “transmission failure” do not show any structural alterations.
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© 1983 Springer-Verlag Berlin Heidelberg
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Kalimo, H., Paljärvi, L., Olsson, Y., Siesjö, B.K. (1983). Structural Aspects of Energy Failure States in the Brain. In: Wiedemann, K., Hoyer, S. (eds) Brain Protection. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69175-1_1
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DOI: https://doi.org/10.1007/978-3-642-69175-1_1
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