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Biogenesis of Plant MicroRNAs

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Non Coding RNAs in Plants

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

MicroRNAs (miRNAs) are small RNAs of ∼21 nt that regulate multiple biological pathways in complex organisms. They are defined by their specific biogenesis that involves the precise excision from an imperfect fold-back precursor. In plants, the ribonuclease III DICER-LIKE1 (DCL1) assisted by accessory proteins cleaves the precursor to release the miRNA. In general, the processing complex recognizes a 15-nt lower stem located below the miRNA in the precursors to produce the first cleavage, which is then followed by a second cut that releases the small RNA. Plant precursors are, however, very variable in size and shape, and not all of them are processed in the same way. The conserved miR319/159 precursors are cleaved in a loop-to-base direction by several successive DCL1 cuts. The situation seems to be even more complex if newly evolved miRNAs are also taken into account. The emerging picture suggests a high plasticity of the miRNA processing machinery.

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Acknowledgments

The work was supported by fellowships from CONICET to JM and NB; JP is a CONICET researcher and received grants from HFSP, ANPCyT, and HHMI.

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Authors and Affiliations

  1. Instituto de Biología Molecular y Celular de Rosario, Suipacha 531, 2000, Rosario, Argentina

    Julieta L. Mateos, Nicolás G. Bologna & Javier F. Palatnik

  2. Max-Planck-Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829, Cologne, Germany

    Julieta L. Mateos

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  1. Julieta L. Mateos
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  2. Nicolás G. Bologna
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  3. Javier F. Palatnik
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Correspondence to Javier F. Palatnik .

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  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Mateos, J.L., Bologna, N.G., Palatnik, J.F. (2011). Biogenesis of Plant MicroRNAs. In: Erdmann, V., Barciszewski, J. (eds) Non Coding RNAs in Plants. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19454-2_16

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