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Sperm-Immobilizing Antibody and Its Target Antigen (CD52)

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Immune Infertility

Abstract

Complement-dependent sperm-immobilizing antibodies (SI-Abs) are exclusively detected in the serum of infertile women. We generated a number of sperm-immobilizing monoclonal antibodies to examine antigenic epitopes for SI-Abs. The epitope for Mab H6–3C4, a human monoclonal antibody generated from peripheral B lymphocytes of a patient with strong SI-Abs was found to be present in the carbohydrate moieties of CD52. CD52 is known as a glycosylphosphatidylinositol (GPI) anchor glycoprotein present in lymphocytes and male reproductive tracts (mrt) including mature sperm and seminal plasma. However, the immunochemical property of mrt-CD52 is different from that of CD52 in the lymphocytes. In this article, biological and immunological functions of mrt-CD52 epitope analyses for different monoclonal antibodies reactive to mrt-CD52 are described.

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Authors and Affiliations

  1. Laboratory of Developmental Biology and Reproduction, Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan

    Akiko Hasegawa

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  1. Akiko Hasegawa
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  2. Koji Koyama
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Correspondence to Akiko Hasegawa .

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Editors and Affiliations

  1. Klinik für Andrologie und Venerologie, Universitätsklinikum Marburg, Deutschhausstr. 9, Marburg, 35033, Germany

    Walter K.H. Krause

  2. School of Medicine, West Virginia University, Morgantown, 26506, U.S.A.

    Rajesh K. Naz

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© 2009 Springer-Verlag Berlin Heidelberg

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Hasegawa, A., Koyama, K. (2009). Sperm-Immobilizing Antibody and Its Target Antigen (CD52). In: Krause, W., Naz, R. (eds) Immune Infertility. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01379-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-01379-9_11

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  • Print ISBN: 978-3-642-01378-2

  • Online ISBN: 978-3-642-01379-9

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