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Sperm Immobilizing Antibody and Its Target Antigen

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Immune Infertility

Abstract

Complement-dependent sperm-immobilizing antibodies (SI-Abs) are detected exclusively in the serum of infertile women. In this chapter, first we suggest a treatment protocol for these infertile patients based on antibody titers. Second, we describe the identification and characterization of an antigenic epitope for SI-Ab. A number of sperm immobilizing monoclonal antibodies were generated to examine the antigenic epitopes for SI-Abs. Among them, a human monoclonal antibody (Mab H6-3C4) was established from the peripheral B lymphocytes of a patient with strong SI-Abs. The epitope for Mab H6-3C4 was found to be the carbohydrate moieties of CD52. CD52 is known as a glycosyl-phosphatidyl inositol (GPI) anchor glycoprotein present in lymphocytes and male reproductive tracts (mrt) including mature sperm and seminal plasma. However, the immunochemical properties of mrt-CD52 are different from these of lymphocyte CD52. This article describes the biological and immunological functions of mrt-CD52 and a possible mechanism of sperm impairment by the corresponding antibody.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hyogo College of Medicine, Mukogawa-cho, 1-1, Nishinomiya, Japan, 663-8501

    Akiko Hasegawa PhD & Hiroaki Shibahara MD, PhD

  2. Advanced Fertility Center of Fuchu Nozomi, Fuchu Institute of Reproductive Medicine, Osaka, Japan

    Minoru Shigeta MD, PhD

Authors
  1. Akiko Hasegawa PhD
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  2. Minoru Shigeta MD, PhD
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  3. Hiroaki Shibahara MD, PhD
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Corresponding author

Correspondence to Akiko Hasegawa PhD .

Editor information

Editors and Affiliations

  1. Department of Dermatology and Allergology, University Hospital, Philipp University, Marburg, Germany

    Walter K.H. Krause

  2. Department of Obstetrics and Gynecology, School of Medicine, West Virgina University, Morgantown, USA

    Rajesh K. Naz

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Hasegawa, A., Shigeta, M., Shibahara, H. (2017). Sperm Immobilizing Antibody and Its Target Antigen. In: Krause, W., Naz, R. (eds) Immune Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-40788-3_11

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  • DOI: https://doi.org/10.1007/978-3-319-40788-3_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40786-9

  • Online ISBN: 978-3-319-40788-3

  • eBook Packages: MedicineMedicine (R0)

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