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Causes of Immune Infertility in Women with Anti-sperm Antibody (ASA)

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Gamete Immunology

Abstract

Some of the anti-sperm antibodies (ASAs) have been shown to be highly related with reproductive failures. In them, sperm-immobilizing antibodies have been shown to be well related with refractory infertility.

The presence of ASA, especially sperm-immobilizing antibodies, in the sera of infertile women has been shown to inhibit sperm migration in the female genital tract. Such antibodies can also exert inhibitory effects on various stages of sperm-egg interaction and subsequent embryo development in vitro. However, ASA might have little impact on recurrent pregnancy loss (RPL).

In this chapter, the topic for the causes of immune infertility in women with ASA is provided.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan

    Hiroaki Shibahara

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  1. Hiroaki Shibahara
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Correspondence to Hiroaki Shibahara .

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  1. Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan

    Hiroaki Shibahara

  2. Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan

    Akiko Hasegawa

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Shibahara, H. (2022). Causes of Immune Infertility in Women with Anti-sperm Antibody (ASA). In: Shibahara, H., Hasegawa, A. (eds) Gamete Immunology. Springer, Singapore. https://doi.org/10.1007/978-981-16-9625-1_3

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