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The Mechanisms of Genomic Imprinting

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Genomic Imprinting

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 25))

Abstract

Genomic imprinting can be regarded as one of many variants of epigenetic modes of gene regulation in eukaryotic cells. There is no a priori reason, therefore, to invoke fundamentally novel mechanisms to explain the imprinting phenomenon in mammals. For example, the different factors involved in imprinting, such as the stable propagation of different chromatin states that repress or permit gene transcription, are well-known entities in a wide range of eukaryotic cells (see Pirotta Chap. 10, and Geramisova and Corces Chap. 11, this vol.). From this point of view, we should perhaps consider the mechanism(s) of imprinting as being the unusual result of combinatory events that occur regularly on an evolutionary scale.

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Authors and Affiliations

  1. Institut für Humangenetik, Universitätsklinikum Essen, Essen, Germany

    Bernhard Horsthemke

  2. Wellcome/CRC Institute, Cambridge, UK

    Azim Surani

  3. Department of Biochemistry, University of Dublin, Dublin, Ireland

    Tharapell James

  4. Department of Animal Development and Genetics, Uppsala University, Uppsala, Sweden

    Rolf Ohlsson

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  1. Bernhard Horsthemke
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  2. Azim Surani
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  3. Tharapell James
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  4. Rolf Ohlsson
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Editors and Affiliations

  1. Dept. of Animal Development and Genetics, University of Uppsala, Norbyvägen 18 A, 75236, Uppsala, Sweden

    Rolf Ohlsson

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Horsthemke, B., Surani, A., James, T., Ohlsson, R. (1999). The Mechanisms of Genomic Imprinting. In: Ohlsson, R. (eds) Genomic Imprinting. Results and Problems in Cell Differentiation, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69111-2_5

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  • DOI: https://doi.org/10.1007/978-3-540-69111-2_5

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