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Matrix-attachment regions in the mouse Chromosome 7F imprinted domain

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Abstract

We have mapped the matrix-attachment regions (MARs) in 200 kilobases of the mouse Chromosome (Chr) 7F imprinted domain. MARs are genetic elements known to have effects in ris on methylation at nonimprinted loci. The imprinting of the Igf2 and Ins2 genes is dependent on the transcription of the downstream H19 gene. The transcription of H19 is dependent in turn on its methylation status. The cis-acting regulators of methylation at this site are not known. As MARs are potential regulators not only of methylation but also other elements of genomic imprinting, we mapped the MARs within the 200 kilobases around H19. This report describes the mapping of four MARs from this region.

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Authors and Affiliations

  1. Department of Genetics, Yale University School of Medicine, 06520, New Haven, Connecticut, USA

    John M. Greally & James McGrath

  2. Department of Paediatrics, Yale University School of Medicine, 06520, New Haven, Connecticut, USA

    Mary E. Guinness, James McGrath & Sharon Zemel

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  1. John M. Greally
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  2. Mary E. Guinness
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  3. James McGrath
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  4. Sharon Zemel
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Additional information

The nucleotide sequence data reported in this paper have been submitted to GenBank and are assigned the accession numbers U71190-3 and U71209.

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Greally, J.M., Guinness, M.E., McGrath, J. et al. Matrix-attachment regions in the mouse Chromosome 7F imprinted domain. Mammalian Genome 8, 805–810 (1997). https://doi.org/10.1007/s003359900583

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  • DOI: https://doi.org/10.1007/s003359900583

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